FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002548557> ?p ?o ?g. }

• W2002548557 endingPage "218" @default.
• W2002548557 startingPage "206" @default.
• W2002548557 abstract "Common variable immunodeficiency (CVI) represents a group of familial and sporadic diseases characterized by a range of B-cell, T-cell, and macrophage defects. A defect in T-cell activation, involving reduced proliferation and IL-2 production after stimulation with OKT3 antibody, has been described previously. In the present study we found that these defects could be corrected in vitro by adding phorbol myristate acetate (PMA) to OKT3-stimulated peripheral blood mononuclear cells (PBMC) of 14 patients with CVI. PBMC of 6 out of 7 patients with CVI studied also exhibited a profound defect in IL-2 receptor expression when incubated with OKT3 antibody. IL-2 receptor expression after stimulation with PMA alone was normal, indicating that the OKT3- but not the PMA-induced pathway of IL-2 receptor expression was defective. On the RNA level, the genes for IL-2 and IL-2 receptor were expressed after stimulation with OKT3 antibody. IL-2 and IL-2 receptor gene expression were normal, indicating a possible post-transcriptional defect. To investigate whether the defect in T-cell activation was at the macrophage or the T-cell level, we prepared adherent cells and monocyte-depleted T cells (E+) from 3 patients with CVI and from normal blood donors. Incubating CVI E+ cells with normal adherent cells resulted in normal proliferation and IL-2 production in the presence of OKT3, whereas incubation of normal E+ cells with adherent cells from patients with CVI under the same conditions showed reduced IL-2 production and proliferation, suggesting the macrophage as the origin of the failure in T-cell activation in the patients with CVI studied. Inhibition by macrophage-secreted prostaglandins was excluded by failure to correct the IL-2 production and proliferation defects in the presence of indomethacin." @default.
• W2002548557 created "2016-06-24" @default.
• W2002548557 creator A5006104596 @default.
• W2002548557 creator A5012976716 @default.
• W2002548557 creator A5016684079 @default.
• W2002548557 creator A5039142066 @default.
• W2002548557 creator A5043060412 @default.
• W2002548557 creator A5048065837 @default.
• W2002548557 creator A5069208658 @default.
• W2002548557 creator A5082920254 @default.
• W2002548557 creator A5084039929 @default.
• W2002548557 date "1987-08-01" @default.
• W2002548557 modified "2023-10-15" @default.
• W2002548557 title "T-cell activation defect in common variable immunodeficiency: Restoration by phorbol myristate acetate (PMA) or allogeneic macrophages" @default.
• W2002548557 cites W1502513877 @default.
• W2002548557 cites W1963808526 @default.
• W2002548557 cites W1963984598 @default.
• W2002548557 cites W1968799461 @default.
• W2002548557 cites W1972978214 @default.
• W2002548557 cites W1981070246 @default.
• W2002548557 cites W1981099238 @default.
• W2002548557 cites W2001692359 @default.
• W2002548557 cites W2005453873 @default.
• W2002548557 cites W2012292566 @default.
• W2002548557 cites W2038680186 @default.
• W2002548557 cites W2072697986 @default.
• W2002548557 cites W2075338554 @default.
• W2002548557 cites W2091519877 @default.
• W2002548557 cites W2145727693 @default.
• W2002548557 cites W2151988463 @default.
• W2002548557 cites W2318787087 @default.
• W2002548557 cites W2411103801 @default.
• W2002548557 cites W4252684946 @default.
• W2002548557 doi "https://doi.org/10.1016/0090-1229(87)90066-3" @default.
• W2002548557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3111766" @default.
• W2002548557 hasPublicationYear "1987" @default.
• W2002548557 type Work @default.
• W2002548557 sameAs 2002548557 @default.
• W2002548557 citedByCount "38" @default.
• W2002548557 countsByYear W20025485572014 @default.
• W2002548557 countsByYear W20025485572017 @default.
• W2002548557 countsByYear W20025485572019 @default.
• W2002548557 crossrefType "journal-article" @default.
• W2002548557 hasAuthorship W2002548557A5006104596 @default.
• W2002548557 hasAuthorship W2002548557A5012976716 @default.
• W2002548557 hasAuthorship W2002548557A5016684079 @default.
• W2002548557 hasAuthorship W2002548557A5039142066 @default.
• W2002548557 hasAuthorship W2002548557A5043060412 @default.
• W2002548557 hasAuthorship W2002548557A5048065837 @default.
• W2002548557 hasAuthorship W2002548557A5069208658 @default.
• W2002548557 hasAuthorship W2002548557A5082920254 @default.
• W2002548557 hasAuthorship W2002548557A5084039929 @default.
• W2002548557 hasConcept C134018914 @default.
• W2002548557 hasConcept C137061746 @default.
• W2002548557 hasConcept C153911025 @default.
• W2002548557 hasConcept C159654299 @default.
• W2002548557 hasConcept C170493617 @default.
• W2002548557 hasConcept C202751555 @default.
• W2002548557 hasConcept C203014093 @default.
• W2002548557 hasConcept C24998067 @default.
• W2002548557 hasConcept C2776090121 @default.
• W2002548557 hasConcept C2776433325 @default.
• W2002548557 hasConcept C2777371288 @default.
• W2002548557 hasConcept C2778690821 @default.
• W2002548557 hasConcept C2779244956 @default.
• W2002548557 hasConcept C2781184567 @default.
• W2002548557 hasConcept C2993002077 @default.
• W2002548557 hasConcept C55493867 @default.
• W2002548557 hasConcept C86803240 @default.
• W2002548557 hasConcept C8891405 @default.
• W2002548557 hasConceptScore W2002548557C134018914 @default.
• W2002548557 hasConceptScore W2002548557C137061746 @default.
• W2002548557 hasConceptScore W2002548557C153911025 @default.
• W2002548557 hasConceptScore W2002548557C159654299 @default.
• W2002548557 hasConceptScore W2002548557C170493617 @default.
• W2002548557 hasConceptScore W2002548557C202751555 @default.
• W2002548557 hasConceptScore W2002548557C203014093 @default.
• W2002548557 hasConceptScore W2002548557C24998067 @default.
• W2002548557 hasConceptScore W2002548557C2776090121 @default.
• W2002548557 hasConceptScore W2002548557C2776433325 @default.
• W2002548557 hasConceptScore W2002548557C2777371288 @default.
• W2002548557 hasConceptScore W2002548557C2778690821 @default.
• W2002548557 hasConceptScore W2002548557C2779244956 @default.
• W2002548557 hasConceptScore W2002548557C2781184567 @default.
• W2002548557 hasConceptScore W2002548557C2993002077 @default.
• W2002548557 hasConceptScore W2002548557C55493867 @default.
• W2002548557 hasConceptScore W2002548557C86803240 @default.
• W2002548557 hasConceptScore W2002548557C8891405 @default.
• W2002548557 hasIssue "2" @default.
• W2002548557 hasLocation W20025485571 @default.
• W2002548557 hasLocation W20025485572 @default.
• W2002548557 hasOpenAccess W2002548557 @default.
• W2002548557 hasPrimaryLocation W20025485571 @default.
• W2002548557 hasRelatedWork W2026232544 @default.
• W2002548557 hasRelatedWork W2047209980 @default.
• W2002548557 hasRelatedWork W2049162920 @default.
• W2002548557 hasRelatedWork W2057804252 @default.
• W2002548557 hasRelatedWork W2087976276 @default.

• next