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• W2002556306 abstract "Rho family GTPases are critical regulators in determining and maintaining cell polarity. In Saccharomyces cerevisiae, Rho3 and Cdc42 play important but distinct roles in regulating polarized exocytosis and overall polarity. Cdc42 is highly polarized during bud emergence and is specifically required for exocytosis at this stage. In contrast, Rho3 appears to play an important role during the isotropic growth of larger buds. Using a novel monoclonal antibody against Rho3, we find that Rho3 localizes to the cell surface in a dispersed pattern which is clearly distinct from that of Cdc42. Using chimeric forms of these GTPases, we demonstrate that a small region at the N terminus is necessary and sufficient to confer Rho3 localization and function onto Cdc42. Analysis of this domain reveals two essential elements responsible for distinguishing function. First, palmitoylation of a cysteine residue by the Akr1 palmitoyltransferase is required both for the switch of function and the switch of localization properties of this domain. Second, two basic residues distal to the palmitoylation site are required for regulating binding affinity with the Exo70 and Sec3 effectors. This demonstrates the importance of localization and effector binding in determining how these GTPases evolved specific functions at distinct stages of polarized growth." @default.
• W2002556306 created "2016-06-24" @default.
• W2002556306 creator A5064038244 @default.
• W2002556306 creator A5086058826 @default.
• W2002556306 date "2010-11-01" @default.
• W2002556306 modified "2023-10-14" @default.
• W2002556306 title "The Function of Two Rho Family GTPases Is Determined by Distinct Patterns of Cell Surface Localization" @default.
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• W2002556306 doi "https://doi.org/10.1128/mcb.00366-10" @default.
• W2002556306 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2953063" @default.
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