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- W2002557788 abstract "The enantioselectivity of lipase-catalyzed kinetic resolutions has been measured at various temperatures in binary mixtures of solvents. Varying the solvent composition and temperature had a profound effect on the enantiomeric ratio. The values for delta delta H(R-S)(#) and delta delta S(R-S)(#), calculated from the E values measured at various temperatures, were estimated as a function of the solvent composition. By plotting delta delta H(R-S)(#) versus delta delta S(R-S)(#) as a function of the solvent composition, an extreme was observed. The resulting hairpin-type enthalpy-entropy compensation plots can be described by assuming the presence of two thermodynamically distinct physical states, displaying different enantioselectivities, that are in equilibrium with one another. Changing the solvent composition results in a change in the equilibrium constant K(eq) for the two states. The intriguing bell-shaped curves of the enantioselectivity versus solvent composition observed for lipase-catalyzed kinetic resolutions can be described assuming a linear correlation for the logarithm of K(eq) and the solvent composition. Thus, a simulation of the two-state model adequately describes the solvent effects found for lipase-catalyzed kinetic resolutions in binary mixtures of solvents and possibly in series of homologous organic solvents." @default.
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- W2002557788 date "2000-01-01" @default.
- W2002557788 modified "2023-09-23" @default.
- W2002557788 title "Solvent effect on lipase enantioselectivity. Evidence for the presence of two thermodynamic states" @default.
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- W2002557788 doi "https://doi.org/10.1002/1097-0290(20001105)70:3<278::aid-bit5>3.0.co;2-i" @default.
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