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- W2002565058 abstract "Introduction: Previous studies have shown that fetal gender had influence on various pregnancy complications and prenatal diagnostic biochemical markers. We have evaluated, whether elevation of amniotic fluid alpha-fetoprotein (AF-AFP) is associated with fetal sex and whether a sex-related difference can help to identify pregnancies with AFP-associated malformations or poor pregnancy outcome.Material and methods: From our database, we obtained 6461 singleton gestations with absolute values and corresponding multiples of the median (MoM) for AF-AFP for the period database April 1997–March 1999. In all instances high-resolution ultrasonography was performed before amniocentesis to measure biparietal diameter. Patients with AF-AFP ≥2 MoM were identified, details of pregnancy outcome were obtained and compared to matched-pair-controls having AF-AFP <2 MoM.Results: A total of 262 patients showed AF-AFP levels ≥2 MoM. Outcome information was available in 232 cases (88.6%) including all cases with fetal anomalies recorded at ultrasonographic examination. Of these fetuses significantly more had male gender (147 male fetuses vs. 85 female, P < 0005). Having a positive screen result in the risk of AFP-associated malformations was significantly higher for female fetuses (25 female fetuses (29.4%) vs. 22 male fetuses (15%) with AFP-associated malformations, P < 0025). Pregnancies with false positive AF-AFP had a significantly higher risk for poor pregnancy outcome compared with pregnancies having normal AF-AFP (11 fetal losses (59%) from 185 vs. two fetal losses (0.9%) from 232, P < 0025) but fetal gender had no significant influence.Conclusions: Measuring AF-AFP routinely in amniotic fluid obtained for cytogenetic evaluation is a cheap method to identify fetuses, on which high-resolution ultrasonography in a level 3 center should be focused. Adjusting the cut-off MoM to 2.5 for male and to 2.0 for female fetuses halves the false-positive rate from 3.4 to 1.7 without affecting the detection rate of 95% in our population. Larger studies are required to determine suitable sex-adjusted cut-off values." @default.
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- W2002565058 date "2001-10-01" @default.
- W2002565058 modified "2023-09-27" @default.
- W2002565058 title "Gender-adjusted multiples of the median in amniotic fluid alpha-fetoprotein-screening for neural-tube defects halve false-positive rate without affecting detection rate" @default.
- W2002565058 doi "https://doi.org/10.1046/j.1469-0705.2001.abs23-4.x" @default.
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