Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002568575> ?p ?o ?g. }
- W2002568575 endingPage "257" @default.
- W2002568575 startingPage "248" @default.
- W2002568575 abstract "Abstract The role of the aromatic hydrocarbon receptor (AhR) in transcriptional regulation of the human cyclooxygenase-2 (COX-2) gene remains elusive. We report that the AhR-ligands benzo[a]pyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced transcription activity of COX-2 in breast cancer MCF-7 cells. The TCDD-dependent activation of the COX-2 promoter was abrogated by mutation of 2 xenobiotic response elements (XREs) = CGTG). We found that TCDD stimulated the binding of the AhR to COX-2 and cytochrome P4501A1 (CYP1A1) oligonucleotides containing consensus XREs. Conversely, the cotreatment with TCDD plus a mixture of conjugated linoleic acid (CLA) or selected CLA isomers prevented (CLAmix = t10,c12-CLA > c9,t11-CLA) the induction of transcription from the COX-2 promoter. The TCDD-induced binding of the AhR to COX-2 and CYP1A1 oligonucleotides was repressed by cotreatment with CLA (t10,c12-CLA > c9,t11-CLA), and the AhR antagonists, 3-methoxy-4-naphthoflavone, and resveratrol. We conclude that the AhR may be a suitable target for prophylactic strategies that target COX-2 expression." @default.
- W2002568575 created "2016-06-24" @default.
- W2002568575 creator A5001096479 @default.
- W2002568575 creator A5037982277 @default.
- W2002568575 creator A5039716341 @default.
- W2002568575 creator A5087203273 @default.
- W2002568575 date "2007-11-07" @default.
- W2002568575 modified "2023-10-14" @default.
- W2002568575 title "Cyclooxygenase-2 Promoter Activation by the Aromatic Hydrocarbon Receptor in Breast Cancer MCF-7 Cells: Repressive Effects of Conjugated Linoleic Acid" @default.
- W2002568575 cites W1929680152 @default.
- W2002568575 cites W1935479846 @default.
- W2002568575 cites W1957928270 @default.
- W2002568575 cites W1970050679 @default.
- W2002568575 cites W1976142725 @default.
- W2002568575 cites W1976720178 @default.
- W2002568575 cites W1982265633 @default.
- W2002568575 cites W1994174646 @default.
- W2002568575 cites W1996162026 @default.
- W2002568575 cites W2000329741 @default.
- W2002568575 cites W2007601885 @default.
- W2002568575 cites W2013891877 @default.
- W2002568575 cites W2018878478 @default.
- W2002568575 cites W2020081339 @default.
- W2002568575 cites W2022953196 @default.
- W2002568575 cites W2026980471 @default.
- W2002568575 cites W2029462907 @default.
- W2002568575 cites W2032110876 @default.
- W2002568575 cites W2039389146 @default.
- W2002568575 cites W2039972806 @default.
- W2002568575 cites W2043091055 @default.
- W2002568575 cites W2046132260 @default.
- W2002568575 cites W2046848792 @default.
- W2002568575 cites W2051729077 @default.
- W2002568575 cites W2053143976 @default.
- W2002568575 cites W2055621185 @default.
- W2002568575 cites W2059344419 @default.
- W2002568575 cites W2060236190 @default.
- W2002568575 cites W2069856924 @default.
- W2002568575 cites W2070646920 @default.
- W2002568575 cites W2073738021 @default.
- W2002568575 cites W2076228017 @default.
- W2002568575 cites W2083862065 @default.
- W2002568575 cites W2087332917 @default.
- W2002568575 cites W2094298387 @default.
- W2002568575 cites W2115613198 @default.
- W2002568575 cites W2119016440 @default.
- W2002568575 cites W2120449490 @default.
- W2002568575 cites W2126853519 @default.
- W2002568575 cites W2129185784 @default.
- W2002568575 cites W2131408519 @default.
- W2002568575 cites W2136175619 @default.
- W2002568575 cites W2138299029 @default.
- W2002568575 cites W2140877509 @default.
- W2002568575 cites W2143474295 @default.
- W2002568575 cites W2145149010 @default.
- W2002568575 cites W2158256320 @default.
- W2002568575 cites W2162584797 @default.
- W2002568575 cites W2172765426 @default.
- W2002568575 doi "https://doi.org/10.1080/01635580701485585" @default.
- W2002568575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18001219" @default.
- W2002568575 hasPublicationYear "2007" @default.
- W2002568575 type Work @default.
- W2002568575 sameAs 2002568575 @default.
- W2002568575 citedByCount "43" @default.
- W2002568575 countsByYear W20025685752012 @default.
- W2002568575 countsByYear W20025685752013 @default.
- W2002568575 countsByYear W20025685752014 @default.
- W2002568575 countsByYear W20025685752015 @default.
- W2002568575 countsByYear W20025685752016 @default.
- W2002568575 countsByYear W20025685752017 @default.
- W2002568575 countsByYear W20025685752018 @default.
- W2002568575 countsByYear W20025685752019 @default.
- W2002568575 countsByYear W20025685752020 @default.
- W2002568575 countsByYear W20025685752021 @default.
- W2002568575 countsByYear W20025685752022 @default.
- W2002568575 countsByYear W20025685752023 @default.
- W2002568575 crossrefType "journal-article" @default.
- W2002568575 hasAuthorship W2002568575A5001096479 @default.
- W2002568575 hasAuthorship W2002568575A5037982277 @default.
- W2002568575 hasAuthorship W2002568575A5039716341 @default.
- W2002568575 hasAuthorship W2002568575A5087203273 @default.
- W2002568575 hasConcept C104317684 @default.
- W2002568575 hasConcept C109541995 @default.
- W2002568575 hasConcept C114246631 @default.
- W2002568575 hasConcept C121608353 @default.
- W2002568575 hasConcept C126322002 @default.
- W2002568575 hasConcept C138885662 @default.
- W2002568575 hasConcept C153911025 @default.
- W2002568575 hasConcept C155701950 @default.
- W2002568575 hasConcept C179926584 @default.
- W2002568575 hasConcept C181199279 @default.
- W2002568575 hasConcept C185592680 @default.
- W2002568575 hasConcept C2777538855 @default.
- W2002568575 hasConcept C2779689624 @default.
- W2002568575 hasConcept C2779780233 @default.
- W2002568575 hasConcept C2780809830 @default.
- W2002568575 hasConcept C2994423619 @default.
- W2002568575 hasConcept C33594762 @default.