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- W2002594429 abstract "<i>Background:</i> Skin lesions from graft-versus-host disease (GVHD) show histological features of epidermal cell death with lymphocyte infiltration. Perforin and granzyme B are involved in the process of apoptosis induced by cytotoxic T lymphocytes (CTL). <i>Objective:</i> To elucidate the role of CTL in the mechanism of epidermal injury in GVHD. <i>Methods:</i> We studied immunohistochemical staining for granzyme B and perforin in the skin lesions of 8 patients who developed GVHD after bone marrow transplantation. <i>Results:</i> Granzyme-B-positive lymphocytes were CD8 positive and were observed in the epidermis of 3 out of 6 specimens in acute GVHD, and of 5 specimens of chronic GVHD except for 1 sclerotic type in which it was negative. Perforin-positive lymphocytes were observed in the epidermis of the specimens from 1 acute and 1 chronic GVHD. <i>Conclusions:</i> Granzyme B derived from CTL may be involved in the mechanisms of epidermal injury in GVHD." @default.
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- W2002594429 date "2001-01-01" @default.
- W2002594429 modified "2023-10-17" @default.
- W2002594429 title "Granzyme-B-Containing Lymphocyte Involvement in Epidermal Injury in Graft-versus-Host Disease" @default.
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- W2002594429 doi "https://doi.org/10.1159/000051606" @default.
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