Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002595848> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2002595848 endingPage "2163" @default.
- W2002595848 startingPage "2156" @default.
- W2002595848 abstract "Phthalic anhydride (PA) is a reactive low molecular weight compound used in the chemical industry. The exposure of PA may lead to work-related airway diseases such as rhinitis, chronic bronchitis, and asthma. The exposure gives rise to an increase in hapten-specific IgG antibodies in workers but with a low presence of specific IgE antibodies. In this study, the binding of PA to human hemoglobin (Hb) in vitro was investigated. Trypsin and Pronase E digestion, LC, LC/MS/MS, GC/MS analysis, and nanoelectrospray hybrid quadrupole time-of-flight MS were used to identify the adducted amino acids of the synthesized PA-Hb conjugates. In the conjugate with the molar ratio 1:0.1, a total of six adducted amino acids were identified. N-Terminal valine was found adducted in both the alpha- and the beta-chains as well as a total of four lysines, Val 1, Lys 16, and Lys 61 on the alpha-chain and Val 1, Lys 66, and Lys 144 on the beta-chain. Two types of lysine adducts were found, a phthalamide and a phthalimide. It was also found that PA differs in its binding site as compared to hexahydrophthalic anhydride. The result of this study suggests several interesting applications of biological monitoring." @default.
- W2002595848 created "2016-06-24" @default.
- W2002595848 creator A5004251967 @default.
- W2002595848 creator A5067377552 @default.
- W2002595848 creator A5071384333 @default.
- W2002595848 creator A5088867243 @default.
- W2002595848 date "2008-10-03" @default.
- W2002595848 modified "2023-10-16" @default.
- W2002595848 title "Identification of Covalent Binding Sites of Phthalic Anhydride in Human Hemoglobin" @default.
- W2002595848 cites W1969013839 @default.
- W2002595848 cites W1978585442 @default.
- W2002595848 cites W1990904002 @default.
- W2002595848 cites W2005267011 @default.
- W2002595848 cites W2015425937 @default.
- W2002595848 cites W2017026505 @default.
- W2002595848 cites W2022700801 @default.
- W2002595848 cites W2023068471 @default.
- W2002595848 cites W2023339741 @default.
- W2002595848 cites W2030232999 @default.
- W2002595848 cites W2037918799 @default.
- W2002595848 cites W2041552684 @default.
- W2002595848 cites W2056024984 @default.
- W2002595848 cites W2066331118 @default.
- W2002595848 cites W2074829588 @default.
- W2002595848 cites W2081871676 @default.
- W2002595848 cites W2093604637 @default.
- W2002595848 cites W2120022554 @default.
- W2002595848 cites W2124002295 @default.
- W2002595848 cites W2127865420 @default.
- W2002595848 cites W2162107343 @default.
- W2002595848 cites W2168599444 @default.
- W2002595848 cites W2169820947 @default.
- W2002595848 cites W2320044005 @default.
- W2002595848 doi "https://doi.org/10.1021/tx800242j" @default.
- W2002595848 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18831565" @default.
- W2002595848 hasPublicationYear "2008" @default.
- W2002595848 type Work @default.
- W2002595848 sameAs 2002595848 @default.
- W2002595848 citedByCount "4" @default.
- W2002595848 countsByYear W20025958482018 @default.
- W2002595848 crossrefType "journal-article" @default.
- W2002595848 hasAuthorship W2002595848A5004251967 @default.
- W2002595848 hasAuthorship W2002595848A5067377552 @default.
- W2002595848 hasAuthorship W2002595848A5071384333 @default.
- W2002595848 hasAuthorship W2002595848A5088867243 @default.
- W2002595848 hasConcept C159654299 @default.
- W2002595848 hasConcept C181199279 @default.
- W2002595848 hasConcept C185592680 @default.
- W2002595848 hasConcept C203014093 @default.
- W2002595848 hasConcept C2776016237 @default.
- W2002595848 hasConcept C2777573094 @default.
- W2002595848 hasConcept C2778401398 @default.
- W2002595848 hasConcept C2778917026 @default.
- W2002595848 hasConcept C2780340462 @default.
- W2002595848 hasConcept C29144244 @default.
- W2002595848 hasConcept C515207424 @default.
- W2002595848 hasConcept C55493867 @default.
- W2002595848 hasConcept C86803240 @default.
- W2002595848 hasConceptScore W2002595848C159654299 @default.
- W2002595848 hasConceptScore W2002595848C181199279 @default.
- W2002595848 hasConceptScore W2002595848C185592680 @default.
- W2002595848 hasConceptScore W2002595848C203014093 @default.
- W2002595848 hasConceptScore W2002595848C2776016237 @default.
- W2002595848 hasConceptScore W2002595848C2777573094 @default.
- W2002595848 hasConceptScore W2002595848C2778401398 @default.
- W2002595848 hasConceptScore W2002595848C2778917026 @default.
- W2002595848 hasConceptScore W2002595848C2780340462 @default.
- W2002595848 hasConceptScore W2002595848C29144244 @default.
- W2002595848 hasConceptScore W2002595848C515207424 @default.
- W2002595848 hasConceptScore W2002595848C55493867 @default.
- W2002595848 hasConceptScore W2002595848C86803240 @default.
- W2002595848 hasIssue "11" @default.
- W2002595848 hasLocation W20025958481 @default.
- W2002595848 hasLocation W20025958482 @default.
- W2002595848 hasOpenAccess W2002595848 @default.
- W2002595848 hasPrimaryLocation W20025958481 @default.
- W2002595848 hasRelatedWork W1989838203 @default.
- W2002595848 hasRelatedWork W2024435679 @default.
- W2002595848 hasRelatedWork W2030076038 @default.
- W2002595848 hasRelatedWork W2033479498 @default.
- W2002595848 hasRelatedWork W2068268841 @default.
- W2002595848 hasRelatedWork W2068547957 @default.
- W2002595848 hasRelatedWork W2076497096 @default.
- W2002595848 hasRelatedWork W2080533976 @default.
- W2002595848 hasRelatedWork W2321795083 @default.
- W2002595848 hasRelatedWork W2182917581 @default.
- W2002595848 hasVolume "21" @default.
- W2002595848 isParatext "false" @default.
- W2002595848 isRetracted "false" @default.
- W2002595848 magId "2002595848" @default.
- W2002595848 workType "article" @default.