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- W2002606435 abstract "ABSTRACT As an alternative to oral prophylaxis for the prevention of tick transmission of Borrelia burgdorferi , we tested antibiotic cream prophylactic formulations in a murine model of spirochete infection. A 4% preparation of doxycycline cream afforded no protection, but a single application of 4% azithromycin cream was 100% protective when applied directly to the tick bite site at the time of tick removal. Indeed, the azithromycin cream was 100% effective when applied at up to 3 days after tick removal and protected 74% of mice exposed to tick bite when applied at up to 2 weeks after tick removal. Azithromycin cream was also protective when applied at a site distal to the tick bite site, suggesting that it was having a systemic effect in addition to a local transdermal effect. Mice that were protected from tick-transmitted infection did not seroconvert and did not infect larval ticks on xenodiagnosis. Azithromycin cream formulations appear to hold promise for Lyme disease prophylaxis." @default.
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- W2002606435 date "2013-10-28" @default.
- W2002606435 modified "2023-09-25" @default.
- W2002606435 title "Efficacy of an Experimental Azithromycin Cream for Prophylaxis of Tick-Transmitted Lyme Disease Spirochete Infection in a Murine Model" @default.
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- W2002606435 doi "https://doi.org/10.1128/aac.01932-13" @default.
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