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• W2002607039 abstract "We investigated naïve CD4 T-cell homeostasis in relapsing–remitting multiple sclerosis (RRMS). Quantification of signal joint T-cell receptor excision circles in FACS-isolated CD31hi cells, which correspond closely to CD4 recent thymic emigrants (RTEs), indicates that young patients have reduced generation of CD4 RTEs compared to age-matched controls. In RRMS, compared to controls, CXCR4 analyses indicate age-associated thymic output of progressively immature CD4 RTEs, and Ki-67 data demonstrate altered T-cell proliferative responses that fail to maintain naïve CD4 T-cell numbers with age. Thus, RRMS patients have early thymic involution with compensatory homeostatic peripheral T-cell proliferative responses that may predispose patients to autoreactivity." @default.
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• W2002607039 date "2010-04-01" @default.
• W2002607039 modified "2023-10-17" @default.
• W2002607039 title "Thymic involution and proliferative T-cell responses in multiple sclerosis" @default.
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• W2002607039 doi "https://doi.org/10.1016/j.jneuroim.2010.02.005" @default.
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