FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002607623> ?p ?o ?g. }

• W2002607623 endingPage "152" @default.
• W2002607623 startingPage "145" @default.
• W2002607623 abstract "Epidermal growth factor (EGF) activates a well characterized signal transduction cascade in human A431 epidermoid carcinoma cells. The influence of gravity on EGF-induced EGF-receptor clustering and early gene expression as well as on actin polymerization and actin organization have been investigated. Different signalling pathways induced by the agents TPA, forskolin and A23187 that activate gene expression were tested for sensitivity to gravity. EGF-induced c-fos and c-jun expression were decreased in microgravity. However, constitutive beta-2 microglobulin expression remained unaltered. Under simulated weightlessness conditions EGF- and TPA-induced c-fos expression was decreased, while forskolin- and A23187-induced c-fos expression was independent of the gravity conditions. These results suggest that gravity affects specific signalling pathways. Preliminary results indicate the EGF-induced EGF-receptor clustering remained unaltered irrespective of the gravity conditions. Furthermore, the relative filamentous actin content of steady state A431 cells was enhanced under microgravity conditions and actin filament organization was altered. Under simulated weightlessness actin filament organization in steady state cells as well as in EGF-treated cells was altered as compared to the 1 G reference experiment. Interestingly the microtubule and keratin organization in untreated cells showed no difference with the normal gravity samples. This indicates that gravity may affect specific components of the signal transduction circuitry." @default.
• W2002607623 created "2016-06-24" @default.
• W2002607623 creator A5002361811 @default.
• W2002607623 creator A5035651136 @default.
• W2002607623 creator A5048866123 @default.
• W2002607623 creator A5056922106 @default.
• W2002607623 creator A5057928059 @default.
• W2002607623 creator A5083759143 @default.
• W2002607623 date "1992-01-01" @default.
• W2002607623 modified "2023-09-26" @default.
• W2002607623 title "Identification of specific gravity sensitive signal transduction pathways in human A431 carcinoma cells" @default.
• W2002607623 cites W1894641937 @default.
• W2002607623 cites W1959610847 @default.
• W2002607623 cites W1976002101 @default.
• W2002607623 cites W1977524450 @default.
• W2002607623 cites W2007095495 @default.
• W2002607623 cites W2010228532 @default.
• W2002607623 cites W2039300300 @default.
• W2002607623 cites W2057094603 @default.
• W2002607623 cites W2059193195 @default.
• W2002607623 cites W2060333964 @default.
• W2002607623 cites W2062706311 @default.
• W2002607623 cites W2069378215 @default.
• W2002607623 cites W2078119356 @default.
• W2002607623 cites W2078835916 @default.
• W2002607623 cites W2095381863 @default.
• W2002607623 cites W2128556059 @default.
• W2002607623 cites W2144206181 @default.
• W2002607623 cites W2167948821 @default.
• W2002607623 cites W2218760274 @default.
• W2002607623 doi "https://doi.org/10.1016/0273-1177(92)90277-5" @default.
• W2002607623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11536950" @default.
• W2002607623 hasPublicationYear "1992" @default.
• W2002607623 type Work @default.
• W2002607623 sameAs 2002607623 @default.
• W2002607623 citedByCount "29" @default.
• W2002607623 countsByYear W20026076232012 @default.
• W2002607623 countsByYear W20026076232013 @default.
• W2002607623 countsByYear W20026076232015 @default.
• W2002607623 countsByYear W20026076232016 @default.
• W2002607623 countsByYear W20026076232017 @default.
• W2002607623 countsByYear W20026076232019 @default.
• W2002607623 countsByYear W20026076232020 @default.
• W2002607623 countsByYear W20026076232022 @default.
• W2002607623 countsByYear W20026076232023 @default.
• W2002607623 crossrefType "journal-article" @default.
• W2002607623 hasAuthorship W2002607623A5002361811 @default.
• W2002607623 hasAuthorship W2002607623A5035651136 @default.
• W2002607623 hasAuthorship W2002607623A5048866123 @default.
• W2002607623 hasAuthorship W2002607623A5056922106 @default.
• W2002607623 hasAuthorship W2002607623A5057928059 @default.
• W2002607623 hasAuthorship W2002607623A5083759143 @default.
• W2002607623 hasConcept C104317684 @default.
• W2002607623 hasConcept C125705527 @default.
• W2002607623 hasConcept C1491633281 @default.
• W2002607623 hasConcept C150194340 @default.
• W2002607623 hasConcept C170493617 @default.
• W2002607623 hasConcept C185592680 @default.
• W2002607623 hasConcept C2776362946 @default.
• W2002607623 hasConcept C2779276759 @default.
• W2002607623 hasConcept C2781018059 @default.
• W2002607623 hasConcept C29537977 @default.
• W2002607623 hasConcept C47170353 @default.
• W2002607623 hasConcept C55493867 @default.
• W2002607623 hasConcept C62478195 @default.
• W2002607623 hasConcept C86803240 @default.
• W2002607623 hasConcept C95444343 @default.
• W2002607623 hasConceptScore W2002607623C104317684 @default.
• W2002607623 hasConceptScore W2002607623C125705527 @default.
• W2002607623 hasConceptScore W2002607623C1491633281 @default.
• W2002607623 hasConceptScore W2002607623C150194340 @default.
• W2002607623 hasConceptScore W2002607623C170493617 @default.
• W2002607623 hasConceptScore W2002607623C185592680 @default.
• W2002607623 hasConceptScore W2002607623C2776362946 @default.
• W2002607623 hasConceptScore W2002607623C2779276759 @default.
• W2002607623 hasConceptScore W2002607623C2781018059 @default.
• W2002607623 hasConceptScore W2002607623C29537977 @default.
• W2002607623 hasConceptScore W2002607623C47170353 @default.
• W2002607623 hasConceptScore W2002607623C55493867 @default.
• W2002607623 hasConceptScore W2002607623C62478195 @default.
• W2002607623 hasConceptScore W2002607623C86803240 @default.
• W2002607623 hasConceptScore W2002607623C95444343 @default.
• W2002607623 hasIssue "1" @default.
• W2002607623 hasLocation W20026076231 @default.
• W2002607623 hasLocation W20026076232 @default.
• W2002607623 hasOpenAccess W2002607623 @default.
• W2002607623 hasPrimaryLocation W20026076231 @default.
• W2002607623 hasRelatedWork W1976002101 @default.
• W2002607623 hasRelatedWork W1994376676 @default.
• W2002607623 hasRelatedWork W2032512077 @default.
• W2002607623 hasRelatedWork W2093951180 @default.
• W2002607623 hasRelatedWork W2112720712 @default.
• W2002607623 hasRelatedWork W2115683115 @default.
• W2002607623 hasRelatedWork W2116690341 @default.
• W2002607623 hasRelatedWork W2142714117 @default.
• W2002607623 hasRelatedWork W2161276384 @default.
• W2002607623 hasRelatedWork W2415424070 @default.
• W2002607623 hasVolume "12" @default.

• next