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• W2002607777 abstract "Designed to treat osteoporosis, denosumab is a fully human monoclonal antibody to the receptor activator of nuclear factor kappaB ligand (NF-κB) (RANKL, a member of the tumor necrosis factor superfamily of ligands and receptors). It blocks the binding of RANKL to RANK and avoids the activation of NF-κB, a protein complex involved in cellular signaling ( 1 Tornatore L. Thotakura A.K. Bennett J. Moretti M. Franzoso G. The nuclear factor kappa B signaling pathway: Integrating metabolism with inflammation. Trends Cell Biol. 2012; 22: 557-566 Abstract Full Text Full Text PDF PubMed Scopus (327) Google Scholar ). Denosumab reduces the formation, function, and survival of osteoclasts, resulting in decreased bone resorption and increased bone density. Its effectiveness in osteoporosis has been shown in different clinical trials ( 2 Cummings S.R. San M.J. McClung M.R. Siris E.S. Eastell R. Reid I.R. et al. Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med. 2009; 361: 756-765 Crossref PubMed Scopus (2375) Google Scholar , 3 McClung M.R. Lewiecki E.M. Cohen S.B. Bolognese M.A. Woodson G.C. Moffett A.H. et al. Denosumab in postmenopausal women with low bone mineral density. N Engl J Med. 2006; 354: 821-831 Crossref PubMed Scopus (960) Google Scholar , 4 Lewiecki E.M. Miller P.D. McClung M.R. Cohen S.B. Bolognese M.A. Liu Y. et al. Two-year treatment with denosumab (AMG 162) in a randomized phase 2 study of postmenopausal women with low BMD. J Bone Miner Res. 2007; 22: 1832-1841 Crossref PubMed Scopus (277) Google Scholar , 5 Bone H.G. Bolognese M.A. Yuen C.K. Kendler D.L. Wang H. Liu Y. San Martin J. Effects of denosumab on bone mineral density and bone turnover in postmenopausal women. J Clin Endocrinol Metab. 2008; 93: 2149-2157 Crossref PubMed Scopus (334) Google Scholar ). In addition to suppressing osteoclastogenesis, the RANKL/NF-κB system plays a central role in the inflammatory response ( 6 Martin T.J. Paracrine regulation of osteoclast formation and activity: Milestones in discovery. J Musculoskelet Neuronal Interact. 2004; 4: 243-253 PubMed Google Scholar ), including modulation of neuroinflammation ( 7 Nadjar A. Bluthe R.M. May M.J. Dantzer R. Parnet P. Inactivation of the cerebral NFkappaB pathway inhibits interleukin-1beta-induced sickness behavior and c-Fos expression in various brain nuclei. Neuropsychopharmacology. 2005; 30: 1492-1499 Crossref PubMed Scopus (100) Google Scholar ). However, no neuropsychiatric adverse events have been described with denosumab treatment up to now." @default.
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• W2002607777 title "Bipolar Depressive Recurrence Following Treatment with the Human Monoclonal Antibody Denosumab: A Case Report" @default.
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• W2002607777 doi "https://doi.org/10.1016/j.biopsych.2013.06.014" @default.
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