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- W2002618340 abstract "This study shows that regional CMRO 2 can be estimated by means of nonlinear regression using dynamic positron emission tomographic data acquired during 1 min following single-bolus inhalation of 15 O 2 . The feasibility of simultaneous estimation of CBF, cerebral blood volume (CBV), oxygen extraction ratio (OER), and CMRO 2 was assessed by simulations using the model of Mintun et al. Four oxygen metabolic measurements, each consisting of a CBF, CBV, and 15 O 2 bolus study, were carried out on three volunteers. Regional values for CBF, CBV, OER, and CMRO 2 were derived in two ways: from the fits of the time-activity curves of the dynamic 15 O 2 bolus study alone [CMRO 2 (fit)] and from the three separate studies [CMRO 2 (control)]. For the 56 regions of interest analyzed, using a fit interval of 60 s, CMRO 2 (fit) was 93.4 ± 7.8% of CMRO 2 (control) (mean ± SD) with a correlation coefficient of r = 0.95. CMRO 2 (control) ranged from 87 to 290 μmol/min/100 g. Individual simultaneous estimates of CBF, CBV, and OER were not reliable. Finally, we found that the validity of the model was limited in practice to the first minute after tracer inhalation." @default.
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- W2002618340 date "1987-08-01" @default.
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- W2002618340 title "Estimation of Cerebral Oxygen Utilization Rate by Single-Bolus <sup>15</sup>O<sub>2</sub> Inhalation and Dynamic Positron Emission Tomography" @default.
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- W2002618340 doi "https://doi.org/10.1038/jcbfm.1987.83" @default.
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