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• W2002623546 abstract "Interleukin (IL)-10 generally is considered a macrophage deactivating factor and thus inhibits the cell-mediated responses against intracellular parasites. We evaluated the in vitro effects of IL-10 on three different parameters of macrophage function. We found that IL-10 inhibited gamma interferon (IFN-gamma) priming for enhanced O2- release of mouse bone marrow-derived macrophages but had opposing effects on NO2- secretion according to the sequence of the treatment with IL-10 and the agonists of NO2- secretion. Likewise, IL-10 was able to induce a small but consistent degree of bacteriostasis of Mycobacterium avium and, also, to inhibit the bacteriostasis induced by IFN-gamma. Thus, we show that, according to the timing of exposure of macrophages to stimulating and inhibiting cytokines and agonists of their functions, IL-10 shows different effects on macrophage function." @default.
• W2002623546 created "2016-06-24" @default.
• W2002623546 creator A5035074211 @default.
• W2002623546 date "1995-06-01" @default.
• W2002623546 modified "2023-09-30" @default.
• W2002623546 title "Opposing Effects of Interleukin-10 on Mouse Macrophage Functions" @default.
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• W2002623546 doi "https://doi.org/10.1111/j.1365-3083.1995.tb03605.x" @default.
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