Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002643671> ?p ?o ?g. }
- W2002643671 endingPage "83" @default.
- W2002643671 startingPage "77" @default.
- W2002643671 abstract "Methadone is often considered as a second-choice drug alternative to morphine in cancer pain treatment. A lack of information regarding methadone's pharmacokinetic/pharmacodynamic relationships has contributed to limitation in its use in analgesic treatments. However, it has been recently re-evaluated in light of better knowledge of its pharmacological characteristics and wider experience. Concern about the safety of methadone therapy arising because of its long and unpredictable half-life should not deter clinicians from its appropriate use. Methadone is a very useful drug in cancer pain because of its low cost, lack of known metabolites, high oral bioavailability, rapid onset and time to peak analgesic effect, and the long duration of activity which allows for longer intervals between doses. Moreover, methadone has been demonstrated to have a high receptor reserve and to exert some NMDA receptor antagonist effect. A shift from one opioid to methadone is recommended when the side-effect/analgesic balance is unfavourable, as symmetrical patterns of cross-tolerance of opioid agonists have been demonstrated. Different approaches, including the oral PCA, have been proposed to circumvent problems related to its pharmacokinetic properties." @default.
- W2002643671 created "2016-06-24" @default.
- W2002643671 creator A5048307423 @default.
- W2002643671 date "1997-06-01" @default.
- W2002643671 modified "2023-10-13" @default.
- W2002643671 title "Methadone in cancer pain" @default.
- W2002643671 cites W1901514045 @default.
- W2002643671 cites W1916417911 @default.
- W2002643671 cites W1967044871 @default.
- W2002643671 cites W1974386630 @default.
- W2002643671 cites W1983775207 @default.
- W2002643671 cites W1983808625 @default.
- W2002643671 cites W1989357546 @default.
- W2002643671 cites W1989723816 @default.
- W2002643671 cites W1995651172 @default.
- W2002643671 cites W1997271743 @default.
- W2002643671 cites W1999452693 @default.
- W2002643671 cites W2000730231 @default.
- W2002643671 cites W2005348543 @default.
- W2002643671 cites W2009239020 @default.
- W2002643671 cites W2015531834 @default.
- W2002643671 cites W2015578983 @default.
- W2002643671 cites W2017035997 @default.
- W2002643671 cites W2019180279 @default.
- W2002643671 cites W2032279034 @default.
- W2002643671 cites W2036220451 @default.
- W2002643671 cites W2044746762 @default.
- W2002643671 cites W2047181075 @default.
- W2002643671 cites W2047849751 @default.
- W2002643671 cites W2049734416 @default.
- W2002643671 cites W2057643659 @default.
- W2002643671 cites W2060879117 @default.
- W2002643671 cites W2068033959 @default.
- W2002643671 cites W2069157843 @default.
- W2002643671 cites W2070257919 @default.
- W2002643671 cites W2072255226 @default.
- W2002643671 cites W2074462228 @default.
- W2002643671 cites W2084808208 @default.
- W2002643671 cites W2086671164 @default.
- W2002643671 cites W2087740998 @default.
- W2002643671 cites W2092984973 @default.
- W2002643671 cites W2095175844 @default.
- W2002643671 cites W2103888546 @default.
- W2002643671 cites W2119940446 @default.
- W2002643671 cites W2142345888 @default.
- W2002643671 cites W2289938773 @default.
- W2002643671 cites W2333750047 @default.
- W2002643671 cites W2410510208 @default.
- W2002643671 cites W342407924 @default.
- W2002643671 cites W4231599650 @default.
- W2002643671 cites W4243354875 @default.
- W2002643671 cites W4246527325 @default.
- W2002643671 cites W82851191 @default.
- W2002643671 doi "https://doi.org/10.1016/s1090-3801(97)90064-1" @default.
- W2002643671 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15102407" @default.
- W2002643671 hasPublicationYear "1997" @default.
- W2002643671 type Work @default.
- W2002643671 sameAs 2002643671 @default.
- W2002643671 citedByCount "39" @default.
- W2002643671 countsByYear W20026436712012 @default.
- W2002643671 countsByYear W20026436712014 @default.
- W2002643671 countsByYear W20026436712017 @default.
- W2002643671 countsByYear W20026436712018 @default.
- W2002643671 crossrefType "journal-article" @default.
- W2002643671 hasAuthorship W2002643671A5048307423 @default.
- W2002643671 hasConcept C111113717 @default.
- W2002643671 hasConcept C112705442 @default.
- W2002643671 hasConcept C121608353 @default.
- W2002643671 hasConcept C126322002 @default.
- W2002643671 hasConcept C170493617 @default.
- W2002643671 hasConcept C2778767360 @default.
- W2002643671 hasConcept C2778904085 @default.
- W2002643671 hasConcept C2780035454 @default.
- W2002643671 hasConcept C2780820201 @default.
- W2002643671 hasConcept C2781063702 @default.
- W2002643671 hasConcept C42219234 @default.
- W2002643671 hasConcept C71924100 @default.
- W2002643671 hasConcept C98274493 @default.
- W2002643671 hasConceptScore W2002643671C111113717 @default.
- W2002643671 hasConceptScore W2002643671C112705442 @default.
- W2002643671 hasConceptScore W2002643671C121608353 @default.
- W2002643671 hasConceptScore W2002643671C126322002 @default.
- W2002643671 hasConceptScore W2002643671C170493617 @default.
- W2002643671 hasConceptScore W2002643671C2778767360 @default.
- W2002643671 hasConceptScore W2002643671C2778904085 @default.
- W2002643671 hasConceptScore W2002643671C2780035454 @default.
- W2002643671 hasConceptScore W2002643671C2780820201 @default.
- W2002643671 hasConceptScore W2002643671C2781063702 @default.
- W2002643671 hasConceptScore W2002643671C42219234 @default.
- W2002643671 hasConceptScore W2002643671C71924100 @default.
- W2002643671 hasConceptScore W2002643671C98274493 @default.
- W2002643671 hasIssue "2" @default.
- W2002643671 hasLocation W20026436711 @default.
- W2002643671 hasLocation W20026436712 @default.
- W2002643671 hasOpenAccess W2002643671 @default.
- W2002643671 hasPrimaryLocation W20026436711 @default.
- W2002643671 hasRelatedWork W150684406 @default.
- W2002643671 hasRelatedWork W1837738291 @default.