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- W2002651246 abstract "A one-step conversion of l-tryptophan and activated aldehydes (1,2-dicarbonyl compounds) directly to 1-substituted β-carbolines without formation of the tetrahydro derivatives under modified Pictet–Spengler conditions was described. Moreover, a practical application for the synthesis of a natural 1-substituted β-carboline, luzongerine A, isolated from Illigera luzonensis was also successfully carried out utilizing this protocol. The effects of synthetic compounds 11 and 11a on nitric oxide (NO) production in LPS/IFN-γ stimulated RAW 264.7 macrophage cells were evaluated in vitro. They displayed significant dose-dependent inhibition of inducible nitric oxide synthase (iNOS)." @default.
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- W2002651246 date "2006-11-01" @default.
- W2002651246 modified "2023-10-18" @default.
- W2002651246 title "A versatile route to the synthesis of 1-substituted β-carbolines by a single step Pictet–Spengler cyclization" @default.
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- W2002651246 doi "https://doi.org/10.1016/j.tet.2006.08.081" @default.
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