FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002665706> ?p ?o ?g. }

• W2002665706 endingPage "74" @default.
• W2002665706 startingPage "61" @default.
• W2002665706 abstract "White matter (WM) damage has been reported in Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI) in diffusion tensor imaging (DTI) studies. It is, however, unknown how the investigation of multiple tensor indexes in the same patients, can differentiate them from normal aging or relate to patients cognition. Forty-six individuals (15 healthy, 16 a-MCI and 15 AD) were included. Voxel-based tract based spatial-statistics (TBSS) was used to obtain whole-brain maps of main WM bundles for fractional anisotropy (FA), radial diffusivity (DR), axial diffusivity (DA) and mean diffusivity (MD). FA reductions were evidenced among AD patients with posterior predominance. A-MCI patients displayed reduced mean FA in these critical regions, compared to healthy elders. MD increases were widespread in both groups of patients. Interestingly, a-MCI patients exhibited DR increases in overlapping areas of FA shrinkages in AD, whereas DA increases were only observed in AD. Gray matter atrophy explained most DTI differences, except those regarding MD in both groups as well as DR increases in posterior associative pathways among a-MCI cases. FA values were the only DTI measure significantly related to memory performance among patients. Present findings suggest that most DTI-derived changes in AD and a-MCI are largely secondary to gray matter atrophy. Notably however, specific DR signal increases in posterior parts of the inferior fronto-occipital and longitudinal fasciculi may reflect early WM compromise in preclinical dementia, which is independent of atrophy. Finally, global measures of integrity, particularly orientation coherence (FA) of diffusion, appear to be more closely related to the cognitive profile of our patients than indexes reflecting water movement parallel (DA) and perpendicular (DR) to the primary diffusion direction." @default.
• W2002665706 created "2016-06-24" @default.
• W2002665706 creator A5000771869 @default.
• W2002665706 creator A5027053507 @default.
• W2002665706 creator A5027089756 @default.
• W2002665706 creator A5036130181 @default.
• W2002665706 creator A5048601724 @default.
• W2002665706 creator A5048847860 @default.
• W2002665706 creator A5052467488 @default.
• W2002665706 creator A5054762575 @default.
• W2002665706 creator A5062181017 @default.
• W2002665706 creator A5067179973 @default.
• W2002665706 date "2012-01-01" @default.
• W2002665706 modified "2023-10-18" @default.
• W2002665706 title "Multiple DTI index analysis in normal aging, amnestic MCI and AD. Relationship with neuropsychological performance" @default.
• W2002665706 cites W1965842072 @default.
• W2002665706 cites W1968195255 @default.
• W2002665706 cites W1969048570 @default.
• W2002665706 cites W1971817501 @default.
• W2002665706 cites W1972146518 @default.
• W2002665706 cites W1973127790 @default.
• W2002665706 cites W1974681848 @default.
• W2002665706 cites W1976676059 @default.
• W2002665706 cites W1977845408 @default.
• W2002665706 cites W1978316308 @default.
• W2002665706 cites W1981000616 @default.
• W2002665706 cites W1986501555 @default.
• W2002665706 cites W1988279296 @default.
• W2002665706 cites W1994206031 @default.
• W2002665706 cites W1997186465 @default.
• W2002665706 cites W2001867951 @default.
• W2002665706 cites W2004006028 @default.
• W2002665706 cites W2004348670 @default.
• W2002665706 cites W2004757203 @default.
• W2002665706 cites W2006096283 @default.
• W2002665706 cites W2014909648 @default.
• W2002665706 cites W2016606517 @default.
• W2002665706 cites W2016813523 @default.
• W2002665706 cites W2017159332 @default.
• W2002665706 cites W2019401192 @default.
• W2002665706 cites W2021061491 @default.
• W2002665706 cites W2025047388 @default.
• W2002665706 cites W2028942474 @default.
• W2002665706 cites W2036142047 @default.
• W2002665706 cites W2043740536 @default.
• W2002665706 cites W2045464339 @default.
• W2002665706 cites W2046206944 @default.
• W2002665706 cites W2049971330 @default.
• W2002665706 cites W2053509355 @default.
• W2002665706 cites W2058676477 @default.
• W2002665706 cites W2059889028 @default.
• W2002665706 cites W2060295418 @default.
• W2002665706 cites W2063001897 @default.
• W2002665706 cites W2068836969 @default.
• W2002665706 cites W2072524743 @default.
• W2002665706 cites W2077924486 @default.
• W2002665706 cites W2081825327 @default.
• W2002665706 cites W2090014162 @default.
• W2002665706 cites W2091931051 @default.
• W2002665706 cites W2092014599 @default.
• W2002665706 cites W2095235225 @default.
• W2002665706 cites W2115424422 @default.
• W2002665706 cites W2116660899 @default.
• W2002665706 cites W2117311229 @default.
• W2002665706 cites W2118521681 @default.
• W2002665706 cites W2120259577 @default.
• W2002665706 cites W2120463647 @default.
• W2002665706 cites W2123261378 @default.
• W2002665706 cites W2126080113 @default.
• W2002665706 cites W2128106262 @default.
• W2002665706 cites W2128776571 @default.
• W2002665706 cites W2129792115 @default.
• W2002665706 cites W2132131830 @default.
• W2002665706 cites W2133981072 @default.
• W2002665706 cites W2136340921 @default.
• W2002665706 cites W2139158372 @default.
• W2002665706 cites W2147547053 @default.
• W2002665706 cites W2149305117 @default.
• W2002665706 cites W2150667092 @default.
• W2002665706 cites W2151568346 @default.
• W2002665706 cites W2156410705 @default.
• W2002665706 cites W2158766477 @default.
• W2002665706 cites W2161360439 @default.
• W2002665706 cites W2162192631 @default.
• W2002665706 cites W2168247374 @default.
• W2002665706 doi "https://doi.org/10.1016/j.neurobiolaging.2010.02.004" @default.
• W2002665706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20371138" @default.
• W2002665706 hasPublicationYear "2012" @default.
• W2002665706 type Work @default.
• W2002665706 sameAs 2002665706 @default.
• W2002665706 citedByCount "220" @default.
• W2002665706 countsByYear W20026657062012 @default.
• W2002665706 countsByYear W20026657062013 @default.
• W2002665706 countsByYear W20026657062014 @default.
• W2002665706 countsByYear W20026657062015 @default.
• W2002665706 countsByYear W20026657062016 @default.
• W2002665706 countsByYear W20026657062017 @default.
• W2002665706 countsByYear W20026657062018 @default.

• next