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- W2002667743 abstract "Biases toward processing negative versus positive information vary as a function of level of awareness, and are modulated by monoamines. Excessive biases are associated with individual differences in mood and emotional stability, and emotional disorder. Here, we examined the impact of the catechol-O-methyltransferase (COMT) Val(108/158)Met polymorphism, involved in dopamine and norepinephrine catabolism, on both emotional brain function and self-reported negativity bias. COMT genotyping and self-reported level of negativity bias were completed for 46 healthy participants taking part in the Brain Resource International Database. Functional MRI was undertaken during perception of facial expressions of fear and happiness presented under unmasked (consciously identified) and masked (to prevent conscious detection) conditions. Structural MR images were also acquired. A greater number of COMT Met alleles predicted increased activation in brainstem, amygdala, basal ganglia and medial prefrontal regions for conscious fear, but decreased activation for conscious happiness. This pattern was also apparent for brainstem activation for the masked condition. Effects were most apparent for females. These differences could not be explained by gray matter variations. The Met-related profile of activation, particularly prefrontally, predicted greater negativity bias associated with risk for emotional disorder. The findings suggest that the COMT Met allele modulates neural substrates of negative versus positive emotion processing. This effect may contribute to negativity biases, which confer susceptibility for emotional disorders." @default.
- W2002667743 created "2016-06-24" @default.
- W2002667743 creator A5018751073 @default.
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- W2002667743 creator A5087169102 @default.
- W2002667743 date "2010-11-01" @default.
- W2002667743 modified "2023-10-05" @default.
- W2002667743 title "COMT Val108/158Met polymorphism effects on emotional brain function and negativity bias" @default.
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- W2002667743 doi "https://doi.org/10.1016/j.neuroimage.2010.01.084" @default.
- W2002667743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20139013" @default.
- W2002667743 hasPublicationYear "2010" @default.