FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002671738> ?p ?o ?g. }

• W2002671738 endingPage "95" @default.
• W2002671738 startingPage "85" @default.
• W2002671738 abstract "The clinical discoveries that drugs that stimulate 5-HT neurotransmission, either by inhibiting 5-HT uptake or by stimulating postsynaptic receptors directly, have antidepressant properties has stimulated interest in defining the role of the 5-HT receptor system in the clinical effects of antidepressant drugs. Two approaches are reviewed in this paper that address the neurochemical mediation of the therapeutic effects of antidepressant drugs from the standpoint of animal behavior. The first approach utilizes a behavioral response in rats, the forced swimming test, that correlates well with predicting antidepressant drugs in humans. Studies are reviewed that examined serotonergic compounds in the forced swimming test, from the standpoint of identifying better serotonergic mechanisms involved in the antidepressant response. Both 5-HT uptake inhibitors and 5-HT1A receptor agonists produce effects in the forced swimming test that are similar to those of other classes of antidepressant drugs. In contrast, agonists at other 5-HT receptors or 5-HT receptor antagonists do not produce antidepressant-like behavioral effects. Evidence for an important role of 5-HT1A receptors in the antidepressant response is supported by findings that antagonists of 5-HT1A receptors prevent the ability of 5-HT1A receptor agonists to reduce immobility in the forced swimming test. The results of studies interfering with 5-HT neurotransmission, either by inhibition of 5-HT synthesis or by the destruction of 5-HT neurons, favor the idea that the effects of 5-HT1A receptor agonists are produced by the stimulation of postsynaptic 5-HT1A receptors. The second approach for studying the behavioral effects of antidepressant drugs employs drug discrimination studies, conducted using a discriminated taste aversion procedure, to provide a method for studying the discriminative stimulus effects of the antidepressant 5-HT uptake inhibitor sertraline. Rats were trained to discriminate the effects of sertraline (10 mg/kg) from saline. Other 5-HT uptake inhibitors, such as fluoxetine, fluvoxamine and paroxetine, substituted for the sertraline stimulus. High doses of norepinephrine uptake inhibitors, such as desipramine or maprotiline, were required to produce similar effects. These two behavioral approaches promise to be useful for defining the important pharmacological effects associated with the behavioral effects of antidepressant drugs." @default.
• W2002671738 created "2016-06-24" @default.
• W2002671738 creator A5002809420 @default.
• W2002671738 creator A5036462139 @default.
• W2002671738 creator A5049697442 @default.
• W2002671738 date "1994-03-01" @default.
• W2002671738 modified "2023-10-18" @default.
• W2002671738 title "Antidepressant-like behavioral effects of serotonin receptor agonists" @default.
• W2002671738 cites W1965027767 @default.
• W2002671738 cites W1967106802 @default.
• W2002671738 cites W1968030121 @default.
• W2002671738 cites W1969924884 @default.
• W2002671738 cites W1973223338 @default.
• W2002671738 cites W1973386992 @default.
• W2002671738 cites W1975447257 @default.
• W2002671738 cites W1975620409 @default.
• W2002671738 cites W1976573190 @default.
• W2002671738 cites W1979420282 @default.
• W2002671738 cites W1980414664 @default.
• W2002671738 cites W1983336401 @default.
• W2002671738 cites W1989788228 @default.
• W2002671738 cites W1990587716 @default.
• W2002671738 cites W1993980186 @default.
• W2002671738 cites W1994979935 @default.
• W2002671738 cites W2002980127 @default.
• W2002671738 cites W2007801877 @default.
• W2002671738 cites W2008910638 @default.
• W2002671738 cites W2012250334 @default.
• W2002671738 cites W2018927741 @default.
• W2002671738 cites W2023091913 @default.
• W2002671738 cites W2034052846 @default.
• W2002671738 cites W2043021317 @default.
• W2002671738 cites W2045030082 @default.
• W2002671738 cites W2047898526 @default.
• W2002671738 cites W2049375720 @default.
• W2002671738 cites W2057948454 @default.
• W2002671738 cites W2061041824 @default.
• W2002671738 cites W2065817172 @default.
• W2002671738 cites W2068405118 @default.
• W2002671738 cites W2069674327 @default.
• W2002671738 cites W2076048389 @default.
• W2002671738 cites W2079993704 @default.
• W2002671738 cites W2080830237 @default.
• W2002671738 cites W2081539703 @default.
• W2002671738 cites W2083572688 @default.
• W2002671738 cites W2085618627 @default.
• W2002671738 cites W2088053259 @default.
• W2002671738 cites W2091496385 @default.
• W2002671738 cites W2093823567 @default.
• W2002671738 cites W2111965328 @default.
• W2002671738 cites W2128844225 @default.
• W2002671738 cites W4232222949 @default.
• W2002671738 doi "https://doi.org/10.1016/0149-7634(94)90039-6" @default.
• W2002671738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8170624" @default.
• W2002671738 hasPublicationYear "1994" @default.
• W2002671738 type Work @default.
• W2002671738 sameAs 2002671738 @default.
• W2002671738 citedByCount "142" @default.
• W2002671738 countsByYear W20026717382012 @default.
• W2002671738 countsByYear W20026717382013 @default.
• W2002671738 countsByYear W20026717382014 @default.
• W2002671738 countsByYear W20026717382015 @default.
• W2002671738 countsByYear W20026717382016 @default.
• W2002671738 countsByYear W20026717382017 @default.
• W2002671738 countsByYear W20026717382019 @default.
• W2002671738 countsByYear W20026717382020 @default.
• W2002671738 countsByYear W20026717382021 @default.
• W2002671738 countsByYear W20026717382022 @default.
• W2002671738 crossrefType "journal-article" @default.
• W2002671738 hasAuthorship W2002671738A5002809420 @default.
• W2002671738 hasAuthorship W2002671738A5036462139 @default.
• W2002671738 hasAuthorship W2002671738A5049697442 @default.
• W2002671738 hasConcept C126322002 @default.
• W2002671738 hasConcept C136569192 @default.
• W2002671738 hasConcept C15744967 @default.
• W2002671738 hasConcept C169760540 @default.
• W2002671738 hasConcept C170493617 @default.
• W2002671738 hasConcept C197341189 @default.
• W2002671738 hasConcept C200170125 @default.
• W2002671738 hasConcept C25876315 @default.
• W2002671738 hasConcept C2775864247 @default.
• W2002671738 hasConcept C2779177272 @default.
• W2002671738 hasConcept C2781161787 @default.
• W2002671738 hasConcept C37000724 @default.
• W2002671738 hasConcept C53910766 @default.
• W2002671738 hasConcept C71924100 @default.
• W2002671738 hasConcept C98274493 @default.
• W2002671738 hasConceptScore W2002671738C126322002 @default.
• W2002671738 hasConceptScore W2002671738C136569192 @default.
• W2002671738 hasConceptScore W2002671738C15744967 @default.
• W2002671738 hasConceptScore W2002671738C169760540 @default.
• W2002671738 hasConceptScore W2002671738C170493617 @default.
• W2002671738 hasConceptScore W2002671738C197341189 @default.
• W2002671738 hasConceptScore W2002671738C200170125 @default.
• W2002671738 hasConceptScore W2002671738C25876315 @default.
• W2002671738 hasConceptScore W2002671738C2775864247 @default.
• W2002671738 hasConceptScore W2002671738C2779177272 @default.
• W2002671738 hasConceptScore W2002671738C2781161787 @default.

• next