FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002684795> ?p ?o ?g. }

• W2002684795 endingPage "268" @default.
• W2002684795 startingPage "241" @default.
• W2002684795 abstract "Research in the areas of drug delivery and tissue engineering has witnessed tremendous progress in recent years due to their unlimited potential to improve human health. Meanwhile, the development of nanotechnology provides opportunities to characterize, manipulate and organize matter systematically at the nanometer scale. Biomaterials with nano-scale organizations have been used as controlled release reservoirs for drug delivery and artificial matrices for tissue engineering. Drug-delivery systems can be synthesized with controlled composition, shape, size and morphology. Their surface properties can be manipulated to increase solubility, immunocompatibility and cellular uptake. The limitations of current drug delivery systems include suboptimal bioavailability, limited effective targeting and potential cytotoxicity. Promising and versatile nano-scale drug-delivery systems include nanoparticles, nanocapsules, nanotubes, nanogels and dendrimers. They can be used to deliver both small-molecule drugs and various classes of biomacromolecules, such as peptides, proteins, plasmid DNA and synthetic oligodeoxynucleotides. Whereas traditional tissue-engineering scaffolds were based on hydrolytically degradable macroporous materials, current approaches emphasize the control over cell behaviors and tissue formation by nano-scale topography that closely mimics the natural extracellular matrix (ECM). The understanding that the natural ECM is a multifunctional nanocomposite motivated researchers to develop nanofibrous scaffolds through electrospinning or self-assembly. Nanocomposites containing nanocrystals have been shown to elicit active bone growth. Drug delivery and tissue engineering are closely related fields. In fact, tissue engineering can be viewed as a special case of drug delivery where the goal is to accomplish controlled delivery of mammalian cells. Controlled release of therapeutic factors in turn will enhance the efficacy of tissue engineering. From a materials point of view, both the drug-delivery vehicles and tissue-engineering scaffolds need to be biocompatible and biodegradable. The biological functions of encapsulated drugs and cells can be dramatically enhanced by designing biomaterials with controlled organizations at the nanometer scale. This review summarizes the most recent development in utilizing nanostructured materials for applications in drug delivery and tissue engineering." @default.
• W2002684795 created "2016-06-24" @default.
• W2002684795 creator A5042597057 @default.
• W2002684795 creator A5074584646 @default.
• W2002684795 creator A5088140942 @default.
• W2002684795 date "2007-01-01" @default.
• W2002684795 modified "2023-10-11" @default.
• W2002684795 title "Nanostructured materials for applications in drug delivery and tissue engineering" @default.
• W2002684795 cites W10110194 @default.
• W2002684795 cites W1087259 @default.
• W2002684795 cites W1486016704 @default.
• W2002684795 cites W1488673481 @default.
• W2002684795 cites W1520821663 @default.
• W2002684795 cites W1546090007 @default.
• W2002684795 cites W1594437063 @default.
• W2002684795 cites W194566379 @default.
• W2002684795 cites W1948127231 @default.
• W2002684795 cites W1964284889 @default.
• W2002684795 cites W1965150667 @default.
• W2002684795 cites W1965800158 @default.
• W2002684795 cites W1966649591 @default.
• W2002684795 cites W1968074470 @default.
• W2002684795 cites W1968324199 @default.
• W2002684795 cites W1970311802 @default.
• W2002684795 cites W1970751992 @default.
• W2002684795 cites W1970810839 @default.
• W2002684795 cites W1972960507 @default.
• W2002684795 cites W1973712257 @default.
• W2002684795 cites W1974055831 @default.
• W2002684795 cites W1974255059 @default.
• W2002684795 cites W1974784466 @default.
• W2002684795 cites W1976061000 @default.
• W2002684795 cites W1977094429 @default.
• W2002684795 cites W1977504973 @default.
• W2002684795 cites W1978296890 @default.
• W2002684795 cites W1978357008 @default.
• W2002684795 cites W1979361158 @default.
• W2002684795 cites W1980124523 @default.
• W2002684795 cites W1982769493 @default.
• W2002684795 cites W1985744874 @default.
• W2002684795 cites W1986352004 @default.
• W2002684795 cites W1990764536 @default.
• W2002684795 cites W1992078677 @default.
• W2002684795 cites W1992453786 @default.
• W2002684795 cites W1994054444 @default.
• W2002684795 cites W1995305066 @default.
• W2002684795 cites W1996812192 @default.
• W2002684795 cites W1997252239 @default.
• W2002684795 cites W1997881196 @default.
• W2002684795 cites W1998185682 @default.
• W2002684795 cites W1998261124 @default.
• W2002684795 cites W1999377948 @default.
• W2002684795 cites W2000886827 @default.
• W2002684795 cites W2001018320 @default.
• W2002684795 cites W2001197917 @default.
• W2002684795 cites W2001603198 @default.
• W2002684795 cites W2002151233 @default.
• W2002684795 cites W2002661845 @default.
• W2002684795 cites W2003048091 @default.
• W2002684795 cites W2004414761 @default.
• W2002684795 cites W2004695587 @default.
• W2002684795 cites W2004914821 @default.
• W2002684795 cites W2006225923 @default.
• W2002684795 cites W2006682004 @default.
• W2002684795 cites W2006846407 @default.
• W2002684795 cites W2007894622 @default.
• W2002684795 cites W2008039399 @default.
• W2002684795 cites W2008752371 @default.
• W2002684795 cites W2010361035 @default.
• W2002684795 cites W2010542051 @default.
• W2002684795 cites W2011454918 @default.
• W2002684795 cites W2011738849 @default.
• W2002684795 cites W2012295039 @default.
• W2002684795 cites W2013678662 @default.
• W2002684795 cites W2013819035 @default.
• W2002684795 cites W2013841789 @default.
• W2002684795 cites W2014068204 @default.
• W2002684795 cites W2014222237 @default.
• W2002684795 cites W2014354647 @default.
• W2002684795 cites W2014684238 @default.
• W2002684795 cites W2016750917 @default.
• W2002684795 cites W2018326618 @default.
• W2002684795 cites W2019546723 @default.
• W2002684795 cites W2022549879 @default.
• W2002684795 cites W2026547102 @default.
• W2002684795 cites W2027393834 @default.
• W2002684795 cites W2028291660 @default.
• W2002684795 cites W2028596690 @default.
• W2002684795 cites W2028926100 @default.
• W2002684795 cites W2029259783 @default.
• W2002684795 cites W2029749273 @default.
• W2002684795 cites W2030255821 @default.
• W2002684795 cites W2030855909 @default.
• W2002684795 cites W2031434258 @default.
• W2002684795 cites W2032190222 @default.
• W2002684795 cites W2033246037 @default.
• W2002684795 cites W2035709514 @default.
• W2002684795 cites W2036914065 @default.

• next