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- W2002685763 abstract "Fifty years ago it was reported that baker's yeast, Saccharomyces cerevisiae, can form “petite colonie” mutants when treated with the DNA-targeting drug acriflavin. To mark the jubilee of studies on cytoplasmic inheritance, a review of the early work will be presented together with some observations on current developments. The primary emphasis is to address the questions of how loss of mtDNA leads to lethality (ρ0-lethality) in petite-negative yeasts and how S. cerevisiae tolerates elimination of mtDNA. Recent investigations have revealed that ρ0-lethality can be suppressed by specific mutations in the α, β, and γ subunits of the mitochondrial F1-ATPase of the petite-negative yeast Kluyveromyces lactis and by the nuclear ptp alleles in Schizosaccharomyces pombe. In contrast, inactivation of genes coding for F1-ATPase α and β subunits and disruption of AAC2, PGS1/PEL1, and YME1 genes in S. cerevisiae convert this petite-positive yeast into a petite-negative form. Studies on nuclear genes affecting dependence on mtDNA have provided important insight into the functions provided by the mitochondrial genome and the maintenance of structural and functional integrity of the mitochondrial inner membrane." @default.
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- W2002685763 date "1965-10-01" @default.
- W2002685763 modified "2023-09-23" @default.
- W2002685763 title "Separation and characterization of mitochondrial DNA from yeast" @default.
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- W2002685763 doi "https://doi.org/10.1016/0006-291x(65)90100-2" @default.
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