Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002689611> ?p ?o ?g. }
- W2002689611 endingPage "195" @default.
- W2002689611 startingPage "186" @default.
- W2002689611 abstract "The prognosis and treatment of astrocytomas, which are primary brain tumors, vary depending on the grade of the tumor, necessitating a precise preoperative classification. Magnetic resonance spectroscopy (MRS) provides information about metabolites in tissues and is an emerging noninvasive tool to improve diagnostic accuracy in patients with intracranial neoplasia.To investigate whether ex vivo MRS could differentiate World Health Organization grade II (A-II) and IV astrocytomas (glioblastomas; GBM) and to correlate MR spectral profiles with clinical parameters.Patients with A-II and GBM (n = 58) scheduled for surgical resection were enrolled. Tumor specimens were collected during surgery and stored in liquid nitrogen before being analyzed with high-resolution magic angle spinning MRS. The tumors were histopathologically classified according to World Health Organization criteria as GBM (n = 48) and A-II (n = 10).Multivariate analysis of ex vivo proton high-resolution magic angle spinning spectra MRS showed differences in the metabolic profiles of different grades of astrocytomas. A-II had higher levels of glycerophosphocholine and myo-inositol than GBM. The latter had more phosphocholine, glycine, and lipids. We observed a significant metabolic difference between recurrent and nonrecurrent GBM (P < .001). Primary GBM had more phosphocholine than recurrent GBM. A significant correlation (P < .001) between lipid and lactate signals and histologically estimated percentage of necrosis was observed in GBM. Spectral profiles were not correlated with age, survival, or magnetic resonance imaging-defined tumor volume.Ex vivo MRS can differentiate astrocytomas based on their metabolic profiles." @default.
- W2002689611 created "2016-06-24" @default.
- W2002689611 creator A5010579271 @default.
- W2002689611 creator A5015765855 @default.
- W2002689611 creator A5029237819 @default.
- W2002689611 creator A5036697478 @default.
- W2002689611 creator A5041269751 @default.
- W2002689611 creator A5055588336 @default.
- W2002689611 creator A5064756368 @default.
- W2002689611 creator A5076224980 @default.
- W2002689611 creator A5087314005 @default.
- W2002689611 date "2013-02-01" @default.
- W2002689611 modified "2023-10-01" @default.
- W2002689611 title "Differentiating Diffuse World Health Organization Grade II and IV Astrocytomas With Ex Vivo Magnetic Resonance Spectroscopy" @default.
- W2002689611 cites W1932803243 @default.
- W2002689611 cites W1971608228 @default.
- W2002689611 cites W1982064004 @default.
- W2002689611 cites W1983391617 @default.
- W2002689611 cites W1984074861 @default.
- W2002689611 cites W1990494423 @default.
- W2002689611 cites W1991413275 @default.
- W2002689611 cites W1992483596 @default.
- W2002689611 cites W2004225523 @default.
- W2002689611 cites W2023384044 @default.
- W2002689611 cites W2026103498 @default.
- W2002689611 cites W2040827479 @default.
- W2002689611 cites W2040909865 @default.
- W2002689611 cites W2048458879 @default.
- W2002689611 cites W2050417061 @default.
- W2002689611 cites W2051607590 @default.
- W2002689611 cites W2054325077 @default.
- W2002689611 cites W2081935151 @default.
- W2002689611 cites W2083166156 @default.
- W2002689611 cites W2083225173 @default.
- W2002689611 cites W2084681095 @default.
- W2002689611 cites W2086777374 @default.
- W2002689611 cites W2087481249 @default.
- W2002689611 cites W2093431268 @default.
- W2002689611 cites W2094131569 @default.
- W2002689611 cites W2096946132 @default.
- W2002689611 cites W2098722265 @default.
- W2002689611 cites W2103425569 @default.
- W2002689611 cites W2114022902 @default.
- W2002689611 cites W2116134519 @default.
- W2002689611 cites W2116232743 @default.
- W2002689611 cites W2120427205 @default.
- W2002689611 cites W2122380937 @default.
- W2002689611 cites W2124185711 @default.
- W2002689611 cites W2125372543 @default.
- W2002689611 cites W2126817554 @default.
- W2002689611 cites W2126918774 @default.
- W2002689611 cites W2131074715 @default.
- W2002689611 cites W2133175063 @default.
- W2002689611 cites W2134326673 @default.
- W2002689611 cites W2152988035 @default.
- W2002689611 cites W2158681922 @default.
- W2002689611 cites W2160382843 @default.
- W2002689611 cites W2161534743 @default.
- W2002689611 cites W2163038498 @default.
- W2002689611 cites W2168784615 @default.
- W2002689611 cites W361184165 @default.
- W2002689611 doi "https://doi.org/10.1227/neu.0b013e31827b9c57" @default.
- W2002689611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23147779" @default.
- W2002689611 hasPublicationYear "2013" @default.
- W2002689611 type Work @default.
- W2002689611 sameAs 2002689611 @default.
- W2002689611 citedByCount "20" @default.
- W2002689611 countsByYear W20026896112014 @default.
- W2002689611 countsByYear W20026896112015 @default.
- W2002689611 countsByYear W20026896112016 @default.
- W2002689611 countsByYear W20026896112017 @default.
- W2002689611 countsByYear W20026896112018 @default.
- W2002689611 countsByYear W20026896112019 @default.
- W2002689611 countsByYear W20026896112020 @default.
- W2002689611 countsByYear W20026896112021 @default.
- W2002689611 crossrefType "journal-article" @default.
- W2002689611 hasAuthorship W2002689611A5010579271 @default.
- W2002689611 hasAuthorship W2002689611A5015765855 @default.
- W2002689611 hasAuthorship W2002689611A5029237819 @default.
- W2002689611 hasAuthorship W2002689611A5036697478 @default.
- W2002689611 hasAuthorship W2002689611A5041269751 @default.
- W2002689611 hasAuthorship W2002689611A5055588336 @default.
- W2002689611 hasAuthorship W2002689611A5064756368 @default.
- W2002689611 hasAuthorship W2002689611A5076224980 @default.
- W2002689611 hasAuthorship W2002689611A5087314005 @default.
- W2002689611 hasConcept C103191249 @default.
- W2002689611 hasConcept C121332964 @default.
- W2002689611 hasConcept C126838900 @default.
- W2002689611 hasConcept C142724271 @default.
- W2002689611 hasConcept C143409427 @default.
- W2002689611 hasConcept C150903083 @default.
- W2002689611 hasConcept C207001950 @default.
- W2002689611 hasConcept C26291073 @default.
- W2002689611 hasConcept C2776330855 @default.
- W2002689611 hasConcept C2776923060 @default.
- W2002689611 hasConcept C2778227246 @default.
- W2002689611 hasConcept C2778880634 @default.
- W2002689611 hasConcept C2778918659 @default.