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• W2002697889 abstract "Liver injury induces activation of hepatic stellate cells (HSCs) comprising expression of receptors, proliferation, and extracellular matrix synthesis triggered by a network of cytokines provided by damaged hepatocytes, activated Kupffer cells and HSCs. While 6 days after bile duct ligation in rats TGF-β inhibited DNA synthesis in HSCs, it was enhanced after 14 days, indicating a switch from suppression to DNA synthesis stimulation during fibrogenesis. To delineate mechanisms modulating TGF-β function, we analyzed crosstalk with signaling pathways initiated by cytokines in damaged liver. Lipopolysaccharide and tumor necrosis factor-α enhanced proliferation inhibition of TGF-β, whereas interleukin-6, oncostatin M, interleukin-1α, and interleukin-1β did not. Hepatocyte growth factor (HGF) counteracted TGF-β dependent inhibition of DNA synthesis in quiescent HSCs. Since expression of c-met is induced during activation of HSCs and HGF is overrepresented in damaged liver, crosstalk of HGF and TGF-β contributes to loss of TGF-β dependent inhibition of DNA synthesis in HSCs." @default.
• W2002697889 created "2016-06-24" @default.
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• W2002697889 date "2007-02-01" @default.
• W2002697889 modified "2023-09-26" @default.
• W2002697889 title "Loss of TGF-β dependent growth control during HSC transdifferentiation" @default.
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• W2002697889 doi "https://doi.org/10.1016/j.bbrc.2006.12.125" @default.
• W2002697889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17204247" @default.
• W2002697889 hasPublicationYear "2007" @default.
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