Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002700543> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2002700543 abstract "low after mating with male RA-GEF-2 KO mice. Although the body weight and pituitary hormones levels showed no difference between KO and wild-type mice, the weight of testis was significantly low in KO mice. In addition, the concentration and motility of epididymal sperms were decreased. Furthermore, malformed sperms were ubiquitously observed in KO mice. Histological examination showed marked atrophy of the testis and hypospermatogenesis in KO mice. Because RAGEF-2 was expressed on the luminal side of seminiferous tubules, it could be related to the apical ectoplasmic specialization (ES) that maintains the polarity of the spermatids and confers adhesion to Sertoli cells in the semiferous epithelium. CONCLUSIONS: RA-GEF-2 KO mice exhibited marked testicular atrophy and a severe defect in mature sperm formation. Because Rap1, the downstream target of RA-GEF-2, is known to have diverse functions by regulating of cell adhesion mediated by cadherins and integrins, RA-GEF-2 may function as a cell-type-specific regulator which mediates Rap1 activation during the process of spermatogenesis." @default.
- W2002700543 created "2016-06-24" @default.
- W2002700543 creator A5034109577 @default.
- W2002700543 creator A5041878826 @default.
- W2002700543 creator A5041954417 @default.
- W2002700543 creator A5059694214 @default.
- W2002700543 creator A5067691014 @default.
- W2002700543 creator A5073800632 @default.
- W2002700543 creator A5076120482 @default.
- W2002700543 creator A5080745508 @default.
- W2002700543 date "2013-03-01" @default.
- W2002700543 modified "2023-09-27" @default.
- W2002700543 title "35 Candesartan ameliorates cisplatin induced testicular damage and change of expression pattern of testicular podocin" @default.
- W2002700543 doi "https://doi.org/10.1016/s1569-9056(13)60529-1" @default.
- W2002700543 hasPublicationYear "2013" @default.
- W2002700543 type Work @default.
- W2002700543 sameAs 2002700543 @default.
- W2002700543 citedByCount "0" @default.
- W2002700543 crossrefType "journal-article" @default.
- W2002700543 hasAuthorship W2002700543A5034109577 @default.
- W2002700543 hasAuthorship W2002700543A5041878826 @default.
- W2002700543 hasAuthorship W2002700543A5041954417 @default.
- W2002700543 hasAuthorship W2002700543A5059694214 @default.
- W2002700543 hasAuthorship W2002700543A5067691014 @default.
- W2002700543 hasAuthorship W2002700543A5073800632 @default.
- W2002700543 hasAuthorship W2002700543A5076120482 @default.
- W2002700543 hasAuthorship W2002700543A5080745508 @default.
- W2002700543 hasConcept C123765429 @default.
- W2002700543 hasConcept C126322002 @default.
- W2002700543 hasConcept C134018914 @default.
- W2002700543 hasConcept C16685009 @default.
- W2002700543 hasConcept C2776855237 @default.
- W2002700543 hasConcept C2777146197 @default.
- W2002700543 hasConcept C2777892665 @default.
- W2002700543 hasConcept C2779561371 @default.
- W2002700543 hasConcept C2780091579 @default.
- W2002700543 hasConcept C2781068068 @default.
- W2002700543 hasConcept C2781087480 @default.
- W2002700543 hasConcept C2781172350 @default.
- W2002700543 hasConcept C71924100 @default.
- W2002700543 hasConceptScore W2002700543C123765429 @default.
- W2002700543 hasConceptScore W2002700543C126322002 @default.
- W2002700543 hasConceptScore W2002700543C134018914 @default.
- W2002700543 hasConceptScore W2002700543C16685009 @default.
- W2002700543 hasConceptScore W2002700543C2776855237 @default.
- W2002700543 hasConceptScore W2002700543C2777146197 @default.
- W2002700543 hasConceptScore W2002700543C2777892665 @default.
- W2002700543 hasConceptScore W2002700543C2779561371 @default.
- W2002700543 hasConceptScore W2002700543C2780091579 @default.
- W2002700543 hasConceptScore W2002700543C2781068068 @default.
- W2002700543 hasConceptScore W2002700543C2781087480 @default.
- W2002700543 hasConceptScore W2002700543C2781172350 @default.
- W2002700543 hasConceptScore W2002700543C71924100 @default.
- W2002700543 hasLocation W20027005431 @default.
- W2002700543 hasOpenAccess W2002700543 @default.
- W2002700543 hasPrimaryLocation W20027005431 @default.
- W2002700543 hasRelatedWork W1759101078 @default.
- W2002700543 hasRelatedWork W1969677364 @default.
- W2002700543 hasRelatedWork W2032632422 @default.
- W2002700543 hasRelatedWork W2036044975 @default.
- W2002700543 hasRelatedWork W2071415655 @default.
- W2002700543 hasRelatedWork W2093809261 @default.
- W2002700543 hasRelatedWork W2123927793 @default.
- W2002700543 hasRelatedWork W2130335328 @default.
- W2002700543 hasRelatedWork W2140380023 @default.
- W2002700543 hasRelatedWork W2151053811 @default.
- W2002700543 hasRelatedWork W2168046577 @default.
- W2002700543 hasRelatedWork W2245200511 @default.
- W2002700543 hasRelatedWork W2315963349 @default.
- W2002700543 hasRelatedWork W2318601719 @default.
- W2002700543 hasRelatedWork W2767869865 @default.
- W2002700543 hasRelatedWork W2806932183 @default.
- W2002700543 hasRelatedWork W2902354388 @default.
- W2002700543 hasRelatedWork W2999148392 @default.
- W2002700543 hasRelatedWork W3120219457 @default.
- W2002700543 hasRelatedWork W2187737743 @default.
- W2002700543 isParatext "false" @default.
- W2002700543 isRetracted "false" @default.
- W2002700543 magId "2002700543" @default.
- W2002700543 workType "article" @default.