Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002714006> ?p ?o ?g. }
- W2002714006 endingPage "5225" @default.
- W2002714006 startingPage "5218" @default.
- W2002714006 abstract "Fibroblast growth factor receptor 3 (FGFR3) mutations are frequent in superficial urothelial cell carcinoma (UCC). Ras gene mutations are also found in UCC. As oncogenic activation of both FGFR3 and Ras is predicted to result in stimulation of the mitogen-activated protein kinase (MAPK) pathway, we hypothesized that these might be mutually exclusive events. HRAS mutation has been widely studied in UCC, but all three Ras gene family members have not been screened for mutation in the same sample series. We screened 98 bladder tumours and 31 bladder cell lines for mutations in FGFR3, HRAS, NRAS and KRAS2. FGFR3 mutations were present in 54 tumours (55%) and three cell lines (10%), and Ras gene mutations in 13 tumours (13%) and four cell lines (13%). These included mutations in all three Ras genes; ten in HRAS, four in KRAS2 and four in NRAS and these were not associated with either tumour grade or stage. In no cases were Ras and FGFR3 mutation found together. This mutual exclusion suggests that FGFR3 and Ras gene mutation may represent alternative means to confer the same phenotype on UCC cells. If these events have biological equivalence, Ras mutant invasive UCC may represent a novel subgroup." @default.
- W2002714006 created "2016-06-24" @default.
- W2002714006 creator A5014571213 @default.
- W2002714006 creator A5020592939 @default.
- W2002714006 creator A5056737493 @default.
- W2002714006 creator A5064065033 @default.
- W2002714006 creator A5070694349 @default.
- W2002714006 creator A5081066697 @default.
- W2002714006 date "2005-05-09" @default.
- W2002714006 modified "2023-10-17" @default.
- W2002714006 title "FGFR3 and Ras gene mutations are mutually exclusive genetic events in urothelial cell carcinoma" @default.
- W2002714006 cites W1563019250 @default.
- W2002714006 cites W1899090394 @default.
- W2002714006 cites W1905202701 @default.
- W2002714006 cites W1932210666 @default.
- W2002714006 cites W1963530589 @default.
- W2002714006 cites W1966302635 @default.
- W2002714006 cites W1967910095 @default.
- W2002714006 cites W1974932491 @default.
- W2002714006 cites W1980902055 @default.
- W2002714006 cites W1985262370 @default.
- W2002714006 cites W1990443418 @default.
- W2002714006 cites W1994141277 @default.
- W2002714006 cites W202565499 @default.
- W2002714006 cites W2030171920 @default.
- W2002714006 cites W2030500412 @default.
- W2002714006 cites W2031541885 @default.
- W2002714006 cites W2033080437 @default.
- W2002714006 cites W2034318751 @default.
- W2002714006 cites W2039040226 @default.
- W2002714006 cites W2040543332 @default.
- W2002714006 cites W2041793407 @default.
- W2002714006 cites W2055229479 @default.
- W2002714006 cites W2073553044 @default.
- W2002714006 cites W2073683003 @default.
- W2002714006 cites W2075446385 @default.
- W2002714006 cites W2076743657 @default.
- W2002714006 cites W2083516187 @default.
- W2002714006 cites W2089625386 @default.
- W2002714006 cites W2090051661 @default.
- W2002714006 cites W2095104340 @default.
- W2002714006 cites W2095509444 @default.
- W2002714006 cites W2096785399 @default.
- W2002714006 cites W2109694492 @default.
- W2002714006 cites W2112397570 @default.
- W2002714006 cites W2140566800 @default.
- W2002714006 cites W2338801916 @default.
- W2002714006 cites W321785694 @default.
- W2002714006 cites W4251464139 @default.
- W2002714006 doi "https://doi.org/10.1038/sj.onc.1208705" @default.
- W2002714006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15897885" @default.
- W2002714006 hasPublicationYear "2005" @default.
- W2002714006 type Work @default.
- W2002714006 sameAs 2002714006 @default.
- W2002714006 citedByCount "304" @default.
- W2002714006 countsByYear W20027140062012 @default.
- W2002714006 countsByYear W20027140062013 @default.
- W2002714006 countsByYear W20027140062014 @default.
- W2002714006 countsByYear W20027140062015 @default.
- W2002714006 countsByYear W20027140062016 @default.
- W2002714006 countsByYear W20027140062017 @default.
- W2002714006 countsByYear W20027140062018 @default.
- W2002714006 countsByYear W20027140062019 @default.
- W2002714006 countsByYear W20027140062020 @default.
- W2002714006 countsByYear W20027140062021 @default.
- W2002714006 countsByYear W20027140062022 @default.
- W2002714006 countsByYear W20027140062023 @default.
- W2002714006 crossrefType "journal-article" @default.
- W2002714006 hasAuthorship W2002714006A5014571213 @default.
- W2002714006 hasAuthorship W2002714006A5020592939 @default.
- W2002714006 hasAuthorship W2002714006A5056737493 @default.
- W2002714006 hasAuthorship W2002714006A5064065033 @default.
- W2002714006 hasAuthorship W2002714006A5070694349 @default.
- W2002714006 hasAuthorship W2002714006A5081066697 @default.
- W2002714006 hasBestOaLocation W20027140061 @default.
- W2002714006 hasConcept C104317684 @default.
- W2002714006 hasConcept C1167327 @default.
- W2002714006 hasConcept C143065580 @default.
- W2002714006 hasConcept C147708747 @default.
- W2002714006 hasConcept C170493617 @default.
- W2002714006 hasConcept C21790070 @default.
- W2002714006 hasConcept C2777362581 @default.
- W2002714006 hasConcept C2781187634 @default.
- W2002714006 hasConcept C501734568 @default.
- W2002714006 hasConcept C502942594 @default.
- W2002714006 hasConcept C54355233 @default.
- W2002714006 hasConcept C555283112 @default.
- W2002714006 hasConcept C57074206 @default.
- W2002714006 hasConcept C62478195 @default.
- W2002714006 hasConcept C74373430 @default.
- W2002714006 hasConcept C86803240 @default.
- W2002714006 hasConceptScore W2002714006C104317684 @default.
- W2002714006 hasConceptScore W2002714006C1167327 @default.
- W2002714006 hasConceptScore W2002714006C143065580 @default.
- W2002714006 hasConceptScore W2002714006C147708747 @default.
- W2002714006 hasConceptScore W2002714006C170493617 @default.
- W2002714006 hasConceptScore W2002714006C21790070 @default.
- W2002714006 hasConceptScore W2002714006C2777362581 @default.