Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002731591> ?p ?o ?g. }
- W2002731591 endingPage "1203" @default.
- W2002731591 startingPage "1181" @default.
- W2002731591 abstract "There are currently no specific treatments for infection with Dengue virus (DENV) and West Nile Virus (WNV). Drug-discovery programs are underway for both viruses, but as yet no small molecules have advanced to clinical trials. Hepatitis C virus (HCV) is a related flavivirus that has been the focus of intense drug discovery efforts for the last two decades. Many approaches currently being pursued for DENV and WNV have been previously attempted for HCV with varying degrees of success. The experience with HCV may direct DENV and WNV efforts towards approaches with the best chance of success. Based on experience with HCV, the viral polymerase and protease are attractive targets to focus on since these have been most successful to date. Cell-based phenotypic screening may also yield attractive inhibitors. The helicase and methyltransferase enzymes are likely to prove difficult targets and host target approaches are fraught with safety concerns." @default.
- W2002731591 created "2016-06-24" @default.
- W2002731591 creator A5021153088 @default.
- W2002731591 creator A5032908501 @default.
- W2002731591 date "2010-07-01" @default.
- W2002731591 modified "2023-09-27" @default.
- W2002731591 title "Small molecule drug discovery for Dengue and West Nile viruses: applying experience from hepatitis C virus" @default.
- W2002731591 cites W1513149807 @default.
- W2002731591 cites W1570836961 @default.
- W2002731591 cites W1580125578 @default.
- W2002731591 cites W1950741423 @default.
- W2002731591 cites W1964280815 @default.
- W2002731591 cites W1971245203 @default.
- W2002731591 cites W1972162083 @default.
- W2002731591 cites W1972565935 @default.
- W2002731591 cites W1972924392 @default.
- W2002731591 cites W1975797606 @default.
- W2002731591 cites W1977139658 @default.
- W2002731591 cites W1979427503 @default.
- W2002731591 cites W1979614321 @default.
- W2002731591 cites W1981910825 @default.
- W2002731591 cites W1982898421 @default.
- W2002731591 cites W1983863966 @default.
- W2002731591 cites W1987702283 @default.
- W2002731591 cites W1988921312 @default.
- W2002731591 cites W1990701251 @default.
- W2002731591 cites W1991022617 @default.
- W2002731591 cites W1992285108 @default.
- W2002731591 cites W1992336935 @default.
- W2002731591 cites W1995054787 @default.
- W2002731591 cites W1995667567 @default.
- W2002731591 cites W1998660158 @default.
- W2002731591 cites W2001438885 @default.
- W2002731591 cites W2002073253 @default.
- W2002731591 cites W2009406967 @default.
- W2002731591 cites W2010337718 @default.
- W2002731591 cites W2010546204 @default.
- W2002731591 cites W2012051375 @default.
- W2002731591 cites W2012265184 @default.
- W2002731591 cites W2014990343 @default.
- W2002731591 cites W2015822934 @default.
- W2002731591 cites W2016563525 @default.
- W2002731591 cites W2018311444 @default.
- W2002731591 cites W2018673290 @default.
- W2002731591 cites W2020705949 @default.
- W2002731591 cites W2022446123 @default.
- W2002731591 cites W2023181285 @default.
- W2002731591 cites W2023582466 @default.
- W2002731591 cites W2025145799 @default.
- W2002731591 cites W2025494340 @default.
- W2002731591 cites W2025946769 @default.
- W2002731591 cites W2027489658 @default.
- W2002731591 cites W2028064829 @default.
- W2002731591 cites W2029250802 @default.
- W2002731591 cites W2029378170 @default.
- W2002731591 cites W2031117917 @default.
- W2002731591 cites W2037831589 @default.
- W2002731591 cites W2038341037 @default.
- W2002731591 cites W2038601283 @default.
- W2002731591 cites W2039841791 @default.
- W2002731591 cites W2042251142 @default.
- W2002731591 cites W2043976521 @default.
- W2002731591 cites W2044749643 @default.
- W2002731591 cites W2045861647 @default.
- W2002731591 cites W2047620718 @default.
- W2002731591 cites W2048699176 @default.
- W2002731591 cites W2048725564 @default.
- W2002731591 cites W2053213283 @default.
- W2002731591 cites W2053236406 @default.
- W2002731591 cites W2053476322 @default.
- W2002731591 cites W2056700536 @default.
- W2002731591 cites W2057407143 @default.
- W2002731591 cites W2058524504 @default.
- W2002731591 cites W2059095830 @default.
- W2002731591 cites W2062458432 @default.
- W2002731591 cites W2062741582 @default.
- W2002731591 cites W2063887342 @default.
- W2002731591 cites W2063994632 @default.
- W2002731591 cites W2068264550 @default.
- W2002731591 cites W2068430448 @default.
- W2002731591 cites W2069389008 @default.
- W2002731591 cites W2070141267 @default.
- W2002731591 cites W2071218237 @default.
- W2002731591 cites W2072304539 @default.
- W2002731591 cites W2072904045 @default.
- W2002731591 cites W2079866702 @default.
- W2002731591 cites W2085244735 @default.
- W2002731591 cites W2086724355 @default.
- W2002731591 cites W2087028046 @default.
- W2002731591 cites W2089210389 @default.
- W2002731591 cites W2090809993 @default.
- W2002731591 cites W2090885432 @default.
- W2002731591 cites W2090973041 @default.
- W2002731591 cites W2091265811 @default.
- W2002731591 cites W2093414854 @default.
- W2002731591 cites W2096398014 @default.
- W2002731591 cites W2099222314 @default.
- W2002731591 cites W2102575242 @default.