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- W2002732223 endingPage "S83" @default.
- W2002732223 startingPage "S65" @default.
- W2002732223 abstract "The long-term treatment of manic-depressive illness (MDI) likely involves the strategic regulation of signalling pathways and gene expression in critical neuronal circuits. Accumulated evidence has identified signalling pathways, in particular the family of protein kinase C (PKC) isozymes, as targets for the long-term action of lithium. Chronic lithium administration produces a reduction in the expression of PKC alpha and epsilon, as well as a major PKC substrate, MARCKS, which has been implicated in long-term neuroplastic events in the developing and adult brain. More recently, studies have demonstrated robust effects of lithium on another kinase system, GSK-3beta, and on neuroprotective/neurotrophic proteins in the brain. Given the key roles of these signalling cascades in the amplification and integration of signals in the central nervous system, these findings have clear implications not only for research into the neurobiology of MDI, but also for the future development of novel and innovative treatment strategies." @default.
- W2002732223 created "2016-06-24" @default.
- W2002732223 creator A5003681868 @default.
- W2002732223 creator A5047437809 @default.
- W2002732223 creator A5061204435 @default.
- W2002732223 creator A5091032668 @default.
- W2002732223 date "1999-12-01" @default.
- W2002732223 modified "2023-09-26" @default.
- W2002732223 title "Signalling pathways in the brain: Cellular transduction of mood stabilisation in the treatment of manic-depressive illness" @default.
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