Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002738924> ?p ?o ?g. }
- W2002738924 endingPage "1424" @default.
- W2002738924 startingPage "1407" @default.
- W2002738924 abstract "Introduction: The therapeutic efficacy of perorally administered drugs is often obscured by their poor oral bioavailability (BA) and low metabolic stability in the gastrointestinal tract (GIT). Solid lipid nanoparticles (SLNs) have emerged as potential BA enhancer vehicles for various Class II, III and IV drug molecules. Area covered: This review examines the recent advancements in SLN technology, with regards to oral drug delivery. The discussion critically examines the effect of various key constituents on SLN absorption and their applications in oral drug delivery. The relationship between the complexity of absorption (and various factors involved during absorption, including particle size), stability and the self-emulsifying ability of the lipids used has been explored. Expert opinion: The protective effect of SLNs, coupled with their sustained/controlled release properties, prevents drugs/macromolecules from premature degradation and improves their stability in the GIT. An extensive literature survey reveals that direct peroral administration of SLNs improves the BA of drugs by 2- to 25-fold. Overall, the ease of large-scale production, avoidance of organic solvents and improvement of oral BA make SLNs a potential BA enhancer vehicle for various Class II, III and IV drugs." @default.
- W2002738924 created "2016-06-24" @default.
- W2002738924 creator A5046435702 @default.
- W2002738924 creator A5057122986 @default.
- W2002738924 creator A5086101197 @default.
- W2002738924 date "2011-08-11" @default.
- W2002738924 modified "2023-10-16" @default.
- W2002738924 title "Solid lipid nanoparticles: an oral bioavailability enhancer vehicle" @default.
- W2002738924 cites W1486016704 @default.
- W2002738924 cites W1495600513 @default.
- W2002738924 cites W1553373140 @default.
- W2002738924 cites W1579046626 @default.
- W2002738924 cites W1594437063 @default.
- W2002738924 cites W1963935732 @default.
- W2002738924 cites W1964896591 @default.
- W2002738924 cites W1968464905 @default.
- W2002738924 cites W1971120211 @default.
- W2002738924 cites W1974148324 @default.
- W2002738924 cites W1977755432 @default.
- W2002738924 cites W1977929750 @default.
- W2002738924 cites W1979326401 @default.
- W2002738924 cites W1984584366 @default.
- W2002738924 cites W1990107581 @default.
- W2002738924 cites W1997988583 @default.
- W2002738924 cites W1999761664 @default.
- W2002738924 cites W2002547755 @default.
- W2002738924 cites W2007893172 @default.
- W2002738924 cites W2009990878 @default.
- W2002738924 cites W2011607617 @default.
- W2002738924 cites W2014144492 @default.
- W2002738924 cites W2019124020 @default.
- W2002738924 cites W2026558149 @default.
- W2002738924 cites W2028258807 @default.
- W2002738924 cites W2036358136 @default.
- W2002738924 cites W2038457912 @default.
- W2002738924 cites W2045746229 @default.
- W2002738924 cites W2046845840 @default.
- W2002738924 cites W2047298886 @default.
- W2002738924 cites W2048444860 @default.
- W2002738924 cites W2050029045 @default.
- W2002738924 cites W2054189154 @default.
- W2002738924 cites W2054273338 @default.
- W2002738924 cites W2054727211 @default.
- W2002738924 cites W2055449190 @default.
- W2002738924 cites W2060208262 @default.
- W2002738924 cites W2069947692 @default.
- W2002738924 cites W2077623418 @default.
- W2002738924 cites W2077870718 @default.
- W2002738924 cites W2081926138 @default.
- W2002738924 cites W2082009989 @default.
- W2002738924 cites W2090530492 @default.
- W2002738924 cites W2091368749 @default.
- W2002738924 cites W2094108005 @default.
- W2002738924 cites W2094968130 @default.
- W2002738924 cites W2106239827 @default.
- W2002738924 cites W2107682048 @default.
- W2002738924 cites W2117576781 @default.
- W2002738924 cites W2123174763 @default.
- W2002738924 cites W2125198898 @default.
- W2002738924 cites W2126462892 @default.
- W2002738924 cites W2128863256 @default.
- W2002738924 cites W2129411530 @default.
- W2002738924 cites W2135738686 @default.
- W2002738924 cites W2147883214 @default.
- W2002738924 cites W2150471474 @default.
- W2002738924 cites W2160651357 @default.
- W2002738924 cites W2166279159 @default.
- W2002738924 cites W2171245233 @default.
- W2002738924 cites W25951409 @default.
- W2002738924 doi "https://doi.org/10.1517/17425247.2011.604311" @default.
- W2002738924 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21831007" @default.
- W2002738924 hasPublicationYear "2011" @default.
- W2002738924 type Work @default.
- W2002738924 sameAs 2002738924 @default.
- W2002738924 citedByCount "216" @default.
- W2002738924 countsByYear W20027389242012 @default.
- W2002738924 countsByYear W20027389242013 @default.
- W2002738924 countsByYear W20027389242014 @default.
- W2002738924 countsByYear W20027389242015 @default.
- W2002738924 countsByYear W20027389242016 @default.
- W2002738924 countsByYear W20027389242017 @default.
- W2002738924 countsByYear W20027389242018 @default.
- W2002738924 countsByYear W20027389242019 @default.
- W2002738924 countsByYear W20027389242020 @default.
- W2002738924 countsByYear W20027389242021 @default.
- W2002738924 countsByYear W20027389242022 @default.
- W2002738924 countsByYear W20027389242023 @default.
- W2002738924 crossrefType "journal-article" @default.
- W2002738924 hasAuthorship W2002738924A5046435702 @default.
- W2002738924 hasAuthorship W2002738924A5057122986 @default.
- W2002738924 hasAuthorship W2002738924A5086101197 @default.
- W2002738924 hasConcept C125287762 @default.
- W2002738924 hasConcept C159985019 @default.
- W2002738924 hasConcept C171250308 @default.
- W2002738924 hasConcept C181389837 @default.
- W2002738924 hasConcept C185592680 @default.
- W2002738924 hasConcept C192562407 @default.
- W2002738924 hasConcept C199529486 @default.