Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002742292> ?p ?o ?g. }
- W2002742292 endingPage "615" @default.
- W2002742292 startingPage "599" @default.
- W2002742292 abstract "The aim of this study was to prepare a drug-in-adhesive patch of nicotine (NIC) and use ion-pair strategy to regulate drug delivery rate. Moreover, the mechanism of how ion-pair strategy regulated drug release was elucidated at molecular level. Formulation factors including pressure sensitive adhesives (PSAs), drug loading and counter ions (C4, C6, C8, C10, and C12) were screened. In vitro release experiment and in vitro transdermal experiment were conducted to determine the rate-limiting step in drug delivery process. FT-IR and molecular modeling were used to characterize the interaction between drug and PSA. Thermal analysis and rheology study were conducted to investigate the mobility variation of PSA. The optimized patch prepared with NIC-C8 had the transdermal profile fairly close to that of the commercial product (p > 0.05). The release rate constants (k) of NIC, NIC-C4 and NIC-C10 were 21.1, 14.4 and 32.4, respectively. Different release rates of NIC ion-pair complexes were attributed to the dual effect of ion-pair strategy on drug release. On one hand, ion-pair strategy enhanced the interaction between drug and PSA, which inhibited drug release. On the other hand, using ion-pair strategy improved the mobility of PSA, which facilitated drug release. Drug release behavior was determined by combined effect of two aspects above. These conclusions provided a new idea for us to regulate drug release behavior from patch." @default.
- W2002742292 created "2016-06-24" @default.
- W2002742292 creator A5071868245 @default.
- W2002742292 date "1998-09-10" @default.
- W2002742292 modified "2023-10-16" @default.
- W2002742292 title "The nicotine transdermal system" @default.
- W2002742292 cites W106063187 @default.
- W2002742292 cites W1545840649 @default.
- W2002742292 cites W1640081073 @default.
- W2002742292 cites W1675801058 @default.
- W2002742292 cites W1781570861 @default.
- W2002742292 cites W1812598206 @default.
- W2002742292 cites W1853594963 @default.
- W2002742292 cites W1866262742 @default.
- W2002742292 cites W1894928914 @default.
- W2002742292 cites W1963818876 @default.
- W2002742292 cites W1965977720 @default.
- W2002742292 cites W1970051466 @default.
- W2002742292 cites W1971085375 @default.
- W2002742292 cites W1971896294 @default.
- W2002742292 cites W1974276099 @default.
- W2002742292 cites W1974416214 @default.
- W2002742292 cites W1978738653 @default.
- W2002742292 cites W1979034154 @default.
- W2002742292 cites W1979744528 @default.
- W2002742292 cites W1981983712 @default.
- W2002742292 cites W1988733693 @default.
- W2002742292 cites W1989309889 @default.
- W2002742292 cites W1992165450 @default.
- W2002742292 cites W1992722623 @default.
- W2002742292 cites W1993222670 @default.
- W2002742292 cites W1996406422 @default.
- W2002742292 cites W1998040272 @default.
- W2002742292 cites W1998061781 @default.
- W2002742292 cites W1998825141 @default.
- W2002742292 cites W1999323355 @default.
- W2002742292 cites W2002518023 @default.
- W2002742292 cites W2005426810 @default.
- W2002742292 cites W2006930810 @default.
- W2002742292 cites W2011501027 @default.
- W2002742292 cites W2015096506 @default.
- W2002742292 cites W2016161929 @default.
- W2002742292 cites W2020172722 @default.
- W2002742292 cites W2020799110 @default.
- W2002742292 cites W2025940424 @default.
- W2002742292 cites W2029128505 @default.
- W2002742292 cites W2043042219 @default.
- W2002742292 cites W2046719353 @default.
- W2002742292 cites W2048203709 @default.
- W2002742292 cites W2051911007 @default.
- W2002742292 cites W2052339006 @default.
- W2002742292 cites W2060208430 @default.
- W2002742292 cites W2061961563 @default.
- W2002742292 cites W2062002432 @default.
- W2002742292 cites W2062192245 @default.
- W2002742292 cites W2063123227 @default.
- W2002742292 cites W2063215441 @default.
- W2002742292 cites W2066871625 @default.
- W2002742292 cites W2068632053 @default.
- W2002742292 cites W207607065 @default.
- W2002742292 cites W2078210941 @default.
- W2002742292 cites W2082447140 @default.
- W2002742292 cites W2084118978 @default.
- W2002742292 cites W2087283239 @default.
- W2002742292 cites W2090773271 @default.
- W2002742292 cites W2094392823 @default.
- W2002742292 cites W2095820408 @default.
- W2002742292 cites W2096690433 @default.
- W2002742292 cites W2098667370 @default.
- W2002742292 cites W2100580932 @default.
- W2002742292 cites W2102200784 @default.
- W2002742292 cites W2109907472 @default.
- W2002742292 cites W2123095952 @default.
- W2002742292 cites W2126259580 @default.
- W2002742292 cites W2149817038 @default.
- W2002742292 cites W2158025579 @default.
- W2002742292 cites W2158478448 @default.
- W2002742292 cites W2164048303 @default.
- W2002742292 cites W2180704072 @default.
- W2002742292 cites W2314557435 @default.
- W2002742292 cites W2320130521 @default.
- W2002742292 cites W2321276948 @default.
- W2002742292 cites W2328901850 @default.
- W2002742292 cites W2331690427 @default.
- W2002742292 cites W2338214979 @default.
- W2002742292 cites W2394810266 @default.
- W2002742292 cites W2404128898 @default.
- W2002742292 cites W2413888977 @default.
- W2002742292 cites W2415783266 @default.
- W2002742292 cites W2418533298 @default.
- W2002742292 cites W2434905930 @default.
- W2002742292 cites W316127110 @default.
- W2002742292 cites W47967586 @default.
- W2002742292 cites W1982007287 @default.
- W2002742292 cites W2110218996 @default.
- W2002742292 cites W2141182348 @default.
- W2002742292 doi "https://doi.org/10.1016/s0738-081x(98)00046-7" @default.
- W2002742292 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9787973" @default.