FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002742465> ?p ?o ?g. }

• W2002742465 endingPage "3550" @default.
• W2002742465 startingPage "3541" @default.
• W2002742465 abstract "Degeneration of the spiral ganglion neurons (SGNs) of the auditory nerve occurs with age and in response to acoustic injury. Histopathological observations suggest that the neural degeneration often begins with an excitotoxic process affecting the afferent dendrites under the inner hair cells (IHCs), however, little is known about the sequence of cellular or molecular events mediating this excitotoxicity. Nuclear factor κB (NFκB) is a transcription factor involved in regulating inflammatory responses and apoptosis in many cell types. NFκB is also associated with intracellular calcium regulation, an important factor in neuronal excitotoxicity. Here, we provide evidence that NFκB can play a central role in the degeneration of SGNs. Mice lacking the p50 subunit of NFκB (p50 −/− mice) showed an accelerated hearing loss with age that was highly associated with an exacerbated excitotoxic-like damage in afferent dendrites under IHCs and an accelerated loss of SGNs. Also, as evidenced by immunostaining intensity, calcium-buffering proteins were significantly elevated in SGNs of the p50 −/− mice. Finally, the knock-out mice exhibited an increased sensitivity to low-level noise exposure. The accelerated hearing loss and neural degeneration with age in the p50 −/− mice occurred in the absence of concomitant hair cell loss and decline of the endocochlear potential. These results indicate that NFκB activity plays an important role in protecting the primary auditory neurons from excitotoxic damage and age-related degeneration. A possible mechanism underlying this protection is that the NFκB activity may help to maintain calcium homeostasis in SGNs." @default.
• W2002742465 created "2016-06-24" @default.
• W2002742465 creator A5008659345 @default.
• W2002742465 creator A5021283680 @default.
• W2002742465 creator A5060703669 @default.
• W2002742465 creator A5060911051 @default.
• W2002742465 creator A5071039284 @default.
• W2002742465 creator A5089053875 @default.
• W2002742465 date "2006-03-29" @default.
• W2002742465 modified "2023-10-16" @default.
• W2002742465 title "Nuclear Factor κB Deficiency Is Associated with Auditory Nerve Degeneration and Increased Noise-Induced Hearing Loss" @default.
• W2002742465 cites W1432022874 @default.
• W2002742465 cites W1502289101 @default.
• W2002742465 cites W1539043236 @default.
• W2002742465 cites W1593856255 @default.
• W2002742465 cites W1755018410 @default.
• W2002742465 cites W1767114057 @default.
• W2002742465 cites W1921685703 @default.
• W2002742465 cites W1956108500 @default.
• W2002742465 cites W1967199635 @default.
• W2002742465 cites W1971214343 @default.
• W2002742465 cites W1972523592 @default.
• W2002742465 cites W1975794556 @default.
• W2002742465 cites W1977653128 @default.
• W2002742465 cites W1986131585 @default.
• W2002742465 cites W1989477058 @default.
• W2002742465 cites W1990549525 @default.
• W2002742465 cites W1992364957 @default.
• W2002742465 cites W1993772503 @default.
• W2002742465 cites W1994647565 @default.
• W2002742465 cites W1997416568 @default.
• W2002742465 cites W1999914498 @default.
• W2002742465 cites W2003092473 @default.
• W2002742465 cites W2004336074 @default.
• W2002742465 cites W2005972504 @default.
• W2002742465 cites W2006258478 @default.
• W2002742465 cites W2008975085 @default.
• W2002742465 cites W2009984517 @default.
• W2002742465 cites W2012717802 @default.
• W2002742465 cites W2014428504 @default.
• W2002742465 cites W2015082850 @default.
• W2002742465 cites W2016575029 @default.
• W2002742465 cites W2018590633 @default.
• W2002742465 cites W2022951839 @default.
• W2002742465 cites W2023575573 @default.
• W2002742465 cites W2031205935 @default.
• W2002742465 cites W2035616122 @default.
• W2002742465 cites W2036100925 @default.
• W2002742465 cites W2037089411 @default.
• W2002742465 cites W2037337146 @default.
• W2002742465 cites W2041008378 @default.
• W2002742465 cites W2041969644 @default.
• W2002742465 cites W2046561180 @default.
• W2002742465 cites W2047823436 @default.
• W2002742465 cites W2049397466 @default.
• W2002742465 cites W2050279035 @default.
• W2002742465 cites W2055585878 @default.
• W2002742465 cites W2056241081 @default.
• W2002742465 cites W2061759133 @default.
• W2002742465 cites W2065117779 @default.
• W2002742465 cites W2065620411 @default.
• W2002742465 cites W2068062158 @default.
• W2002742465 cites W2068909794 @default.
• W2002742465 cites W2069589645 @default.
• W2002742465 cites W2072315530 @default.
• W2002742465 cites W2073811072 @default.
• W2002742465 cites W2074783627 @default.
• W2002742465 cites W2076276094 @default.
• W2002742465 cites W2077145081 @default.
• W2002742465 cites W2078283328 @default.
• W2002742465 cites W2079201863 @default.
• W2002742465 cites W2080062846 @default.
• W2002742465 cites W2082999381 @default.
• W2002742465 cites W2084511589 @default.
• W2002742465 cites W2085571273 @default.
• W2002742465 cites W2085793489 @default.
• W2002742465 cites W2085846904 @default.
• W2002742465 cites W2089067021 @default.
• W2002742465 cites W2090374145 @default.
• W2002742465 cites W2099181688 @default.
• W2002742465 cites W2099976535 @default.
• W2002742465 cites W2110906194 @default.
• W2002742465 cites W2116413476 @default.
• W2002742465 cites W2116421701 @default.
• W2002742465 cites W2122962129 @default.
• W2002742465 cites W2138525727 @default.
• W2002742465 cites W2140689828 @default.
• W2002742465 cites W2155730697 @default.
• W2002742465 cites W2156524972 @default.
• W2002742465 cites W2156625231 @default.
• W2002742465 cites W2161075307 @default.
• W2002742465 cites W2237496182 @default.
• W2002742465 cites W2385769066 @default.
• W2002742465 cites W4251712623 @default.
• W2002742465 cites W4253664863 @default.
• W2002742465 cites W4322703208 @default.
• W2002742465 doi "https://doi.org/10.1523/jneurosci.2488-05.2006" @default.
• W2002742465 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2897814" @default.

• next