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- W2002743304 abstract "We describe a reliable method for obtaining a significantly higher frequency of human cloned T lymphocytes with killer and/or NK-like activity. Human peripheral blood mononuclear cells were treated with recombinant interferon-gamma (rIFN-gamma) and recombinant interleukin-2 (rIL-2) in a culture medium containing autologous serum and were then cloned by single cell micromanipulation. The cloned T lymphocyte populations were tested simultaneously for their ability to proliferate in response to exogenous IL-2, to exhibit lectin-dependent cytolysis and to kill the tumor cell line K562. Results indicate that the cloning technique allowed each isolated T lymphocyte to undergo cell expansion. Furthermore when T cells were pretreated with rIFN-gamma and rIL-2, 88% of the T cell clones were capable of mediating cytotoxicity in the presence of PHA. Moreover one third of the clones which exhibited lectin-dependent lysis were able to kill K562 target cells." @default.
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- W2002743304 date "1986-06-01" @default.
- W2002743304 modified "2023-10-18" @default.
- W2002743304 title "Human T lymphocyte clones with killer or natural killer activity" @default.
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- W2002743304 doi "https://doi.org/10.1016/0022-1759(86)90078-5" @default.
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