Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002769908> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2002769908 endingPage "105" @default.
- W2002769908 startingPage "99" @default.
- W2002769908 abstract "Studies indicate that angiogenesis is important in tissue healing. However, the role of vascular endothelial growth factor (VEGF) in tissue healing has not been established. The aim of the study is to determine whether VEGF has a gastroprotective role in experimental gastric injury.Acute gastric injury was induced in Sprague-Dawley rats by intragastric administration of 100% ethanol. Expression of gastric VEGF was determined in tissue homogenates by enzyme-linked immunosorbent assay and in paraffin-embedded sections by immunohistochemistry. The effect of systemic administration of anti-VEGF antibodies and recombinant VEGF on injury severity was assessed macroscopically and microscopically.Gastric VEGF concentrations peaked at 6 h and again 3 days after acute injury. The presence of VEGF was demonstrated in epithelial cells and in mononuclear cells. Blocking endogenous VEGF effects with anti-VEGF antibodies exacerbated mucosal injury. Administration of recombinant VEGF after the onset of injury reduced the severity of mucosal injury, irrespective of the timing of initial treatment with VEGF. Immunohistochemical detection of vascular endothelial cells revealed that the VEGF-induced mucosal repair is closely related to the degree of angiogenesis.The results provide strong evidence for the role of VEGF in the repair of tissue damage induced by ethanol. The results also show how VEGF may be used in a clinical setting to treat some acute gastric lesions." @default.
- W2002769908 created "2016-06-24" @default.
- W2002769908 creator A5003789179 @default.
- W2002769908 creator A5028162939 @default.
- W2002769908 creator A5050047978 @default.
- W2002769908 creator A5065128587 @default.
- W2002769908 creator A5084794851 @default.
- W2002769908 date "2002-01-01" @default.
- W2002769908 modified "2023-10-14" @default.
- W2002769908 title "Efficacy of Vascular Endothelial Growth Factor in the Treatment of Experimental Gastric Injury" @default.
- W2002769908 cites W1971248512 @default.
- W2002769908 cites W1976402556 @default.
- W2002769908 cites W1992380657 @default.
- W2002769908 cites W2015344488 @default.
- W2002769908 cites W2023788245 @default.
- W2002769908 cites W2114098415 @default.
- W2002769908 cites W2145522340 @default.
- W2002769908 doi "https://doi.org/10.1159/000065591" @default.
- W2002769908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12428069" @default.
- W2002769908 hasPublicationYear "2002" @default.
- W2002769908 type Work @default.
- W2002769908 sameAs 2002769908 @default.
- W2002769908 citedByCount "14" @default.
- W2002769908 countsByYear W20027699082021 @default.
- W2002769908 crossrefType "journal-article" @default.
- W2002769908 hasAuthorship W2002769908A5003789179 @default.
- W2002769908 hasAuthorship W2002769908A5028162939 @default.
- W2002769908 hasAuthorship W2002769908A5050047978 @default.
- W2002769908 hasAuthorship W2002769908A5065128587 @default.
- W2002769908 hasAuthorship W2002769908A5084794851 @default.
- W2002769908 hasConcept C126322002 @default.
- W2002769908 hasConcept C142724271 @default.
- W2002769908 hasConcept C146285616 @default.
- W2002769908 hasConcept C159654299 @default.
- W2002769908 hasConcept C167734588 @default.
- W2002769908 hasConcept C203014093 @default.
- W2002769908 hasConcept C204232928 @default.
- W2002769908 hasConcept C2777025900 @default.
- W2002769908 hasConcept C2779422922 @default.
- W2002769908 hasConcept C2780269544 @default.
- W2002769908 hasConcept C2780394083 @default.
- W2002769908 hasConcept C2781443798 @default.
- W2002769908 hasConcept C71924100 @default.
- W2002769908 hasConceptScore W2002769908C126322002 @default.
- W2002769908 hasConceptScore W2002769908C142724271 @default.
- W2002769908 hasConceptScore W2002769908C146285616 @default.
- W2002769908 hasConceptScore W2002769908C159654299 @default.
- W2002769908 hasConceptScore W2002769908C167734588 @default.
- W2002769908 hasConceptScore W2002769908C203014093 @default.
- W2002769908 hasConceptScore W2002769908C204232928 @default.
- W2002769908 hasConceptScore W2002769908C2777025900 @default.
- W2002769908 hasConceptScore W2002769908C2779422922 @default.
- W2002769908 hasConceptScore W2002769908C2780269544 @default.
- W2002769908 hasConceptScore W2002769908C2780394083 @default.
- W2002769908 hasConceptScore W2002769908C2781443798 @default.
- W2002769908 hasConceptScore W2002769908C71924100 @default.
- W2002769908 hasIssue "2" @default.
- W2002769908 hasLocation W20027699081 @default.
- W2002769908 hasLocation W20027699082 @default.
- W2002769908 hasOpenAccess W2002769908 @default.
- W2002769908 hasPrimaryLocation W20027699081 @default.
- W2002769908 hasRelatedWork W1613798522 @default.
- W2002769908 hasRelatedWork W1946170785 @default.
- W2002769908 hasRelatedWork W2024623214 @default.
- W2002769908 hasRelatedWork W2057131081 @default.
- W2002769908 hasRelatedWork W2140520381 @default.
- W2002769908 hasRelatedWork W2155467443 @default.
- W2002769908 hasRelatedWork W2357263905 @default.
- W2002769908 hasRelatedWork W2975373816 @default.
- W2002769908 hasRelatedWork W3209287588 @default.
- W2002769908 hasRelatedWork W4280518230 @default.
- W2002769908 hasVolume "66" @default.
- W2002769908 isParatext "false" @default.
- W2002769908 isRetracted "false" @default.
- W2002769908 magId "2002769908" @default.
- W2002769908 workType "article" @default.