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- W2002774493 abstract "IN studying the inhibition of partially purified mammalian β-glucuronidase by heavy metal ions, we have found that the cupric ion is a moderate inhibitor, and is potentiated by cysteine. This action of cysteine appears to be limited by the formation of cystine, since the latter reverses inhibition by copper and by other metals. Sodium bisulphite and ascorbic acid were therefore examined as alternative reducing agents. Neither of these agents by itself had any effect on the enzyme activity, but they had an identical action in potentiating inhibition by the cupric ion, as shown in Fig. 1; this process was instantaneous, there being no increase in inhibition on prolonged incubation with the substrate. In the presence of ascorbic acid or bisulphite, the inhibitory power of Cu++ was of the same order as that of Ag+ or Hg++, neither of which was potentiated by the reducing agents. A feasible explanation of these results is that copper inhibition is due to the cuprous, and not the cupric, ion." @default.
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- W2002774493 date "1957-07-01" @default.
- W2002774493 modified "2023-09-25" @default.
- W2002774493 title "Action of Copper on Mammalian β-Glucuronidase" @default.
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- W2002774493 doi "https://doi.org/10.1038/180197a0" @default.
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