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- W2002777195 abstract "The effect of the opiate antagonist naloxone on neurohypophyseal hormone secretion has been investigated in rats given 2% NaCl to drink for 0-9 days. Naloxone elicited a rise in plasma levels of oxytocin (OT), but not arginine-vasopressin (AVP), on days 1-3 only, the greatest response being on day 2. In a further experiment, the OT response to an acute stimulus (1.5 M NaCl, i.p.) was found to be similar in controls and rats drinking 2% NaCl for 7 days, indicating that depletion of readily releasable hormone was not the cause of the loss of sensitivity to naloxone; rather a down-regulation of opiate receptor mechanisms may be responsible. The temporal changes in opiate antagonist-sensitivity in saline-loaded rats may provide a functional paradigm for the investigation of regulatory opiate mechanisms in neural tissue." @default.
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- W2002777195 date "1987-11-01" @default.
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- W2002777195 title "Temporal changes in the activity of endogenous opioid mechanisms regulating oxytocin secretion in saline-loaded rats" @default.
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- W2002777195 doi "https://doi.org/10.1016/0304-3940(87)90128-5" @default.
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