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- W2002778911 abstract "Nervous system growth factors potently stimulate cell function and prevent neuronal death. These broad effects on survival and function arise from direct downstream activation of antiapoptotic pathways, inhibition of proapoptotic pathways, and stimulation of functionally important cellular mechanisms including ERK/MAP kinase and CREB. Thus, as a class, growth factors offer the potential to treat neurodegenerative disorders for the first time by preventing neuronal degeneration rather than compensating for cell loss after it has occurred. Different growth factors affect distinct and specific populations of neurons: the first nervous system growth factor identified, nerve growth factor, potentially stimulates the survival and function of basal forebrain cholinergic neurons, suggesting that nerve growth factor could be a means for reducing the cholinergic component of cell degeneration in Alzheimer disease. This review will discuss the transition of growth factors from preclinical studies to human clinical trials in Alzheimer disease. The implementation of clinical testing of growth factor therapy for neurologic disease has been constrained by the dual need to achieve adequate concentrations of these proteins in specific brain regions containing degenerating neurons, and preventing growth factor spread to nontargeted regions to avoid adverse effects. Gene therapy is one of a limited number of potential methods for achieving these requirements." @default.
- W2002778911 created "2016-06-24" @default.
- W2002778911 creator A5055508729 @default.
- W2002778911 date "2007-04-01" @default.
- W2002778911 modified "2023-10-03" @default.
- W2002778911 title "Nerve Growth Factor Gene Therapy in Alzheimer Disease" @default.
- W2002778911 cites W1509043648 @default.
- W2002778911 cites W1516658808 @default.
- W2002778911 cites W1539302044 @default.
- W2002778911 cites W1609471181 @default.
- W2002778911 cites W1638939027 @default.
- W2002778911 cites W1639832183 @default.
- W2002778911 cites W1842160119 @default.
- W2002778911 cites W1927132367 @default.
- W2002778911 cites W1930427841 @default.
- W2002778911 cites W1963860879 @default.
- W2002778911 cites W1966019489 @default.
- W2002778911 cites W1969349734 @default.
- W2002778911 cites W1971258758 @default.
- W2002778911 cites W1972514500 @default.
- W2002778911 cites W1977405586 @default.
- W2002778911 cites W1980910954 @default.
- W2002778911 cites W1982312003 @default.
- W2002778911 cites W1996001296 @default.
- W2002778911 cites W1996708582 @default.
- W2002778911 cites W1996900261 @default.
- W2002778911 cites W1999667056 @default.
- W2002778911 cites W2003522028 @default.
- W2002778911 cites W2004713321 @default.
- W2002778911 cites W2005780620 @default.
- W2002778911 cites W2008350281 @default.
- W2002778911 cites W2010779836 @default.
- W2002778911 cites W2016843660 @default.
- W2002778911 cites W2018792371 @default.
- W2002778911 cites W2021104084 @default.
- W2002778911 cites W2022599922 @default.
- W2002778911 cites W2022908085 @default.
- W2002778911 cites W2025089255 @default.
- W2002778911 cites W2026745182 @default.
- W2002778911 cites W2031928363 @default.
- W2002778911 cites W2033100622 @default.
- W2002778911 cites W2035051064 @default.
- W2002778911 cites W2036313216 @default.
- W2002778911 cites W2037194302 @default.
- W2002778911 cites W2040700904 @default.
- W2002778911 cites W2040974116 @default.
- W2002778911 cites W2041938779 @default.
- W2002778911 cites W2042812490 @default.
- W2002778911 cites W2044061635 @default.
- W2002778911 cites W2045776001 @default.
- W2002778911 cites W2047945439 @default.
- W2002778911 cites W2049100671 @default.
- W2002778911 cites W2051349037 @default.
- W2002778911 cites W2053684741 @default.
- W2002778911 cites W2055746351 @default.
- W2002778911 cites W2057946562 @default.
- W2002778911 cites W2060646430 @default.
- W2002778911 cites W2061592818 @default.
- W2002778911 cites W2062740121 @default.
- W2002778911 cites W2063695629 @default.
- W2002778911 cites W2064244593 @default.
- W2002778911 cites W2068501914 @default.
- W2002778911 cites W2069050425 @default.
- W2002778911 cites W2069095254 @default.
- W2002778911 cites W2073374252 @default.
- W2002778911 cites W2074744143 @default.
- W2002778911 cites W2076686769 @default.
- W2002778911 cites W2078790263 @default.
- W2002778911 cites W2079490962 @default.
- W2002778911 cites W2084947002 @default.
- W2002778911 cites W2087090756 @default.
- W2002778911 cites W2088479689 @default.
- W2002778911 cites W2092862588 @default.
- W2002778911 cites W2095401453 @default.
- W2002778911 cites W2101821836 @default.
- W2002778911 cites W2103899142 @default.
- W2002778911 cites W2108724455 @default.
- W2002778911 cites W2117164994 @default.
- W2002778911 cites W2117506145 @default.
- W2002778911 cites W2121543539 @default.
- W2002778911 cites W2128960139 @default.
- W2002778911 cites W2133173415 @default.
- W2002778911 cites W2136782227 @default.
- W2002778911 cites W2143265930 @default.
- W2002778911 cites W2146113273 @default.
- W2002778911 cites W2150799457 @default.
- W2002778911 cites W2151934323 @default.
- W2002778911 cites W2152060070 @default.
- W2002778911 cites W2161483044 @default.
- W2002778911 cites W2163407262 @default.
- W2002778911 cites W2171776741 @default.
- W2002778911 cites W2209078744 @default.
- W2002778911 cites W2314133009 @default.
- W2002778911 cites W53218870 @default.
- W2002778911 doi "https://doi.org/10.1097/wad.0b013e318068d6d2" @default.
- W2002778911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17545746" @default.
- W2002778911 hasPublicationYear "2007" @default.
- W2002778911 type Work @default.