FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002783549> ?p ?o ?g. }

• W2002783549 endingPage "1396" @default.
• W2002783549 startingPage "1387" @default.
• W2002783549 abstract "Background: In support of bioanalysis, there has always been a desire to improve detection limits and reduce scale. Microflow LC (MFLC) coupled with MS accomplishes both of these goals. Results: As such, MFLC coupled with an MS system was used to generate bioanalytical validation data that met US FDA criteria. The MFLC–MS/MS data was compared with the same method with the use of conventional HPLC–MS/MS and a more than 14× S/N improvement was found with the MFLC–MS/MS method. Methotrexate was used as a model molecule to demonstrate the validation of the method from human plasma. The MFLC–MS/MS method was demonstrated to be accurate (±7%) and precise (12.9% at the LLOQ and a maximum of 11.6% at all other concentrations) across the dynamic range of the assay (1–1000 ng/ml) and compared well with the HPLC–MS/MS method. The MFLC bioanalytical validation was performed at a flow rate of 35 µl/min on a 0.5-mm inner diameter (I.D.) column, whereas, for the same linear velocities on the 2.0-mm I.D. column, the conventional HPLC bioanalytical validation was performed at 700 µl/min. Since the flow rate of the MFLC system is 20-times less than the HPLC system, the consumable solvent and disposal cost to perform the MFLC validation was significantly less. Conclusion: MFLC–MS/MS can be used to perform bioanalytical method validations with increased MS signal, reduced source contamination and reduced solvent consumption." @default.
• W2002783549 created "2016-06-24" @default.
• W2002783549 creator A5012295666 @default.
• W2002783549 creator A5044320158 @default.
• W2002783549 creator A5046789515 @default.
• W2002783549 date "2013-06-01" @default.
• W2002783549 modified "2023-09-25" @default.
• W2002783549 title "The advantages of microflow LC–MS/MS compared with conventional HPLC–MS/MS for the analysis of methotrexate from human plasma" @default.
• W2002783549 cites W1858496442 @default.
• W2002783549 cites W1973753936 @default.
• W2002783549 cites W1975267705 @default.
• W2002783549 cites W1984336617 @default.
• W2002783549 cites W1984650264 @default.
• W2002783549 cites W1991671417 @default.
• W2002783549 cites W1995070541 @default.
• W2002783549 cites W1999919865 @default.
• W2002783549 cites W2006849765 @default.
• W2002783549 cites W2011126715 @default.
• W2002783549 cites W2018197188 @default.
• W2002783549 cites W2019297097 @default.
• W2002783549 cites W2021420134 @default.
• W2002783549 cites W2029171409 @default.
• W2002783549 cites W2032680924 @default.
• W2002783549 cites W2046479800 @default.
• W2002783549 cites W2048207474 @default.
• W2002783549 cites W2065211758 @default.
• W2002783549 cites W2066928228 @default.
• W2002783549 cites W2066978817 @default.
• W2002783549 cites W2069756383 @default.
• W2002783549 cites W2080605893 @default.
• W2002783549 cites W2080669227 @default.
• W2002783549 cites W2081046742 @default.
• W2002783549 cites W2088922420 @default.
• W2002783549 cites W2120609860 @default.
• W2002783549 cites W2167209294 @default.
• W2002783549 cites W2497735451 @default.
• W2002783549 cites W2937245212 @default.
• W2002783549 doi "https://doi.org/10.4155/bio.13.73" @default.
• W2002783549 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23742308" @default.
• W2002783549 hasPublicationYear "2013" @default.
• W2002783549 type Work @default.
• W2002783549 sameAs 2002783549 @default.
• W2002783549 citedByCount "51" @default.
• W2002783549 countsByYear W20027835492013 @default.
• W2002783549 countsByYear W20027835492014 @default.
• W2002783549 countsByYear W20027835492015 @default.
• W2002783549 countsByYear W20027835492016 @default.
• W2002783549 countsByYear W20027835492017 @default.
• W2002783549 countsByYear W20027835492018 @default.
• W2002783549 countsByYear W20027835492019 @default.
• W2002783549 countsByYear W20027835492020 @default.
• W2002783549 countsByYear W20027835492021 @default.
• W2002783549 countsByYear W20027835492022 @default.
• W2002783549 countsByYear W20027835492023 @default.
• W2002783549 crossrefType "journal-article" @default.
• W2002783549 hasAuthorship W2002783549A5012295666 @default.
• W2002783549 hasAuthorship W2002783549A5044320158 @default.
• W2002783549 hasAuthorship W2002783549A5046789515 @default.
• W2002783549 hasConcept C113196181 @default.
• W2002783549 hasConcept C121332964 @default.
• W2002783549 hasConcept C137535248 @default.
• W2002783549 hasConcept C172120300 @default.
• W2002783549 hasConcept C179998833 @default.
• W2002783549 hasConcept C185592680 @default.
• W2002783549 hasConcept C203014093 @default.
• W2002783549 hasConcept C2781059491 @default.
• W2002783549 hasConcept C3020134792 @default.
• W2002783549 hasConcept C43617362 @default.
• W2002783549 hasConcept C62520636 @default.
• W2002783549 hasConcept C86803240 @default.
• W2002783549 hasConceptScore W2002783549C113196181 @default.
• W2002783549 hasConceptScore W2002783549C121332964 @default.
• W2002783549 hasConceptScore W2002783549C137535248 @default.
• W2002783549 hasConceptScore W2002783549C172120300 @default.
• W2002783549 hasConceptScore W2002783549C179998833 @default.
• W2002783549 hasConceptScore W2002783549C185592680 @default.
• W2002783549 hasConceptScore W2002783549C203014093 @default.
• W2002783549 hasConceptScore W2002783549C2781059491 @default.
• W2002783549 hasConceptScore W2002783549C3020134792 @default.
• W2002783549 hasConceptScore W2002783549C43617362 @default.
• W2002783549 hasConceptScore W2002783549C62520636 @default.
• W2002783549 hasConceptScore W2002783549C86803240 @default.
• W2002783549 hasIssue "11" @default.
• W2002783549 hasLocation W20027835491 @default.
• W2002783549 hasLocation W20027835492 @default.
• W2002783549 hasOpenAccess W2002783549 @default.
• W2002783549 hasPrimaryLocation W20027835491 @default.
• W2002783549 hasRelatedWork W1976068555 @default.
• W2002783549 hasRelatedWork W1984249823 @default.
• W2002783549 hasRelatedWork W2011623110 @default.
• W2002783549 hasRelatedWork W2016967817 @default.
• W2002783549 hasRelatedWork W2036400894 @default.
• W2002783549 hasRelatedWork W2063950674 @default.
• W2002783549 hasRelatedWork W2089132074 @default.
• W2002783549 hasRelatedWork W2145981463 @default.
• W2002783549 hasRelatedWork W2350827710 @default.
• W2002783549 hasRelatedWork W2418246579 @default.
• W2002783549 hasVolume "5" @default.

• next