FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002802632> ?p ?o ?g. }

• W2002802632 endingPage "219" @default.
• W2002802632 startingPage "205" @default.
• W2002802632 abstract "Melarsomine dihydrochloride (RM 340), a drug being developed as an adulticide for treatment of heartworm (Dirofilaria immitis) infection in dogs, was safe and highly effective as a clinical prophylactic agent against naturally acquired infections using Strategic and Tactical Treatment Programs. The Strategic Program involved treatment every 4 months (three series of treatments per year), disregarding the mosquito season (MS), to clear the existing infection at each treatment. The Tactical Program consisted of two series of treatments per year, 4 months apart, with the first one given about the middle of the MS (August) and the second one given after the end of the MS (December). Melarsomine was administered as two i.m. injections (lumbar muscles) of 2.2 mg kg-1 given 3 h apart. A total of 90 heartworm-naive beagles and a number of microfilaremic 'seed' dogs were used. Three similar experiments (30 beagles per experiment) were conducted at selected areas (Georgia, Florida, Louisiana) known to be enzootic for heartworm. At each site, 30 beagles were allocated to six groups of five dogs each, and four of these groups were placed outdoors in April of 1988. Two groups (control and treated) were exposed for 12 months, and the treated group was given melarsomine at 4, 8, and 12 months after exposure was started (Strategic Program). Another group was exposed for 8 months and treated with melarsomine at 4 and 8 months (Tactical Program). One group of tracer (sentinel) beagles was exposed from April to August 1988, one group from August to December 1988, and another from December 1988 to April 1989. April-August and August-December tracers served as controls for the tactically treated dogs. After exposure, all dogs were held indoors for 5 months before necropsy. Blood was collected at 4-5 month intervals and examined for microfilariae (MF) and adult heartworm antigen (enzyme-linked immunosorbent assay, ELISA). Treatment by the Strategic Program was 99% effective, with only one of the total of 15 treated dogs harboring any worms (a single female) at necropsy. Thirteen of the 14 control dogs (93%) exposed for 12 months became infected, with average worm recoveries of 6.8, 5.4, and 25.2 (range 1-45) for the Georgia, Florida, and Louisiana sites, respectively. All of the 13 heartworm-infected control dogs were antigen-positive, and 12 of these were also MF-positive, while none of the strategically treated dogs was either antigen- or MF-positive at necropsy. Tactical treatment of the total of 14 dogs twice per year was 100% effective.(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
• W2002802632 created "2016-06-24" @default.
• W2002802632 creator A5057515334 @default.
• W2002802632 creator A5079897719 @default.
• W2002802632 creator A5083509486 @default.
• W2002802632 creator A5084779857 @default.
• W2002802632 creator A5087925900 @default.
• W2002802632 date "1994-11-01" @default.
• W2002802632 modified "2023-09-27" @default.
• W2002802632 title "Clinical prophylactic activity of melarsomine dihydrochloride (RM 340) against Dirofilaria immitis in heartworm-naive beagles exposed to natural infection in three southeastern states" @default.
• W2002802632 cites W1982335106 @default.
• W2002802632 cites W2029238628 @default.
• W2002802632 cites W2321903105 @default.
• W2002802632 doi "https://doi.org/10.1016/0304-4017(93)00642-c" @default.
• W2002802632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7879379" @default.
• W2002802632 hasPublicationYear "1994" @default.
• W2002802632 type Work @default.
• W2002802632 sameAs 2002802632 @default.
• W2002802632 citedByCount "6" @default.
• W2002802632 countsByYear W20028026322012 @default.
• W2002802632 countsByYear W20028026322014 @default.
• W2002802632 countsByYear W20028026322016 @default.
• W2002802632 countsByYear W20028026322017 @default.
• W2002802632 countsByYear W20028026322018 @default.
• W2002802632 countsByYear W20028026322022 @default.
• W2002802632 crossrefType "journal-article" @default.
• W2002802632 hasAuthorship W2002802632A5057515334 @default.
• W2002802632 hasAuthorship W2002802632A5079897719 @default.
• W2002802632 hasAuthorship W2002802632A5083509486 @default.
• W2002802632 hasAuthorship W2002802632A5084779857 @default.
• W2002802632 hasAuthorship W2002802632A5087925900 @default.
• W2002802632 hasConcept C163698547 @default.
• W2002802632 hasConcept C165901193 @default.
• W2002802632 hasConcept C203014093 @default.
• W2002802632 hasConcept C2522874641 @default.
• W2002802632 hasConcept C2776355835 @default.
• W2002802632 hasConcept C42972112 @default.
• W2002802632 hasConcept C71924100 @default.
• W2002802632 hasConcept C86803240 @default.
• W2002802632 hasConceptScore W2002802632C163698547 @default.
• W2002802632 hasConceptScore W2002802632C165901193 @default.
• W2002802632 hasConceptScore W2002802632C203014093 @default.
• W2002802632 hasConceptScore W2002802632C2522874641 @default.
• W2002802632 hasConceptScore W2002802632C2776355835 @default.
• W2002802632 hasConceptScore W2002802632C42972112 @default.
• W2002802632 hasConceptScore W2002802632C71924100 @default.
• W2002802632 hasConceptScore W2002802632C86803240 @default.
• W2002802632 hasIssue "3" @default.
• W2002802632 hasLocation W20028026321 @default.
• W2002802632 hasLocation W20028026322 @default.
• W2002802632 hasOpenAccess W2002802632 @default.
• W2002802632 hasPrimaryLocation W20028026321 @default.
• W2002802632 hasRelatedWork W1969746910 @default.
• W2002802632 hasRelatedWork W2024869794 @default.
• W2002802632 hasRelatedWork W2040840128 @default.
• W2002802632 hasRelatedWork W2056546572 @default.
• W2002802632 hasRelatedWork W2171511089 @default.
• W2002802632 hasRelatedWork W2334341067 @default.
• W2002802632 hasRelatedWork W2523506607 @default.
• W2002802632 hasRelatedWork W2564041001 @default.
• W2002802632 hasRelatedWork W2900166414 @default.
• W2002802632 hasRelatedWork W2968372393 @default.
• W2002802632 hasVolume "55" @default.
• W2002802632 isParatext "false" @default.
• W2002802632 isRetracted "false" @default.
• W2002802632 magId "2002802632" @default.
• W2002802632 workType "article" @default.