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• W2002802662 abstract "Aim The present study aimed to determine the efficacy and safety of thrombolytic therapy with recombinant tissue plasminogen activator (rt-PA) therapy in older patients compared with younger patients. Methods Using the Fukuoka Stroke Registry, a prospective multicenter study for acute stroke in Japan, we analyzed data of 401 patients with acute ischemic stroke (aged 74.5 ± 13.1 years) treated with thrombolytic therapy using rt-PA. Patients were categorized into two groups according to age: those aged ≥75 years (n = 240) and <75 years (n = 161). Neurological improvement was defined as a decrease in the National Institute of Health Stroke Scale (NIHSS) score of ≥4 during hospitalization or an NIHSS score of 0 at discharge. Good functional outcome was defined as a modified Rankin scale score of 0–2 at 3 months after onset. Results Neurological symptoms at admission were more severe in older patients than in younger patients. Old age (≥75 years) was not associated with neurological deterioration (multivariate-adjusted odds ratio [OR] 0.90, 95% confidence interval [CI] 0.46–1.77), neurological improvement (multivariate-adjusted OR 0.91, 95% CI 0.54–1.53) and symptomatic intracranial hemorrhage (multivariate-adjusted OR 1.11, 95% CI 0.19–8.87). Old age was negatively associated with good functional outcome (multivariate-adjusted OR 0.29, 95% CI 0.16–0.52) and positively associated with in-hospital mortality (multivariate-adjusted OR 19.3, 95% CI 2.4–474.9). Conclusions In patients treated with rt-PA, old age is associated with poor functional outcome and in-hospital mortality. However, the probability of neurological improvement and symptomatic intracranial hemorrhage in older patients is comparable with that in younger patients. Geriatr Gerontol Int 2014; 14: 954–959." @default.
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• W2002802662 date "2013-12-09" @default.
• W2002802662 modified "2023-09-27" @default.
• W2002802662 title "Thrombolytic therapy with intravenous recombinant tissue plasminogen activator in Japanese older patients with acute ischemic stroke: Fukuoka Stroke Registry" @default.
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• W2002802662 doi "https://doi.org/10.1111/ggi.12205" @default.
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