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- W2002803275 endingPage "147" @default.
- W2002803275 startingPage "136" @default.
- W2002803275 abstract "Different pathogens have evolved distinct strategies to promote their survival in host cells. This Review describes the contribution of the endoplasmic reticulum to host defence and the mechanisms by which pathogens interacting with the endoplasmic reticulum subvert the host immune response. A key determinant for the survival of intracellular pathogens is their ability to subvert the cellular processes of the host to establish a compartment that allows replication. Although most microorganisms internalized by host cells are efficiently cleared following fusion with lysosomes, many pathogens have evolved mechanisms to escape this degradation. In this Review, we provide insight into the molecular processes that are targeted by pathogens that interact with the endoplasmic reticulum and thereby subvert the immune response, ensure their survival intracellularly and cause disease. We also discuss how the endoplasmic reticulum 'strikes back' and controls microbial growth." @default.
- W2002803275 created "2016-06-24" @default.
- W2002803275 creator A5029576475 @default.
- W2002803275 creator A5058627531 @default.
- W2002803275 creator A5080222404 @default.
- W2002803275 date "2006-01-13" @default.
- W2002803275 modified "2023-10-17" @default.
- W2002803275 title "Pathogen–endoplasmic-reticulum interactions: in through the out door" @default.
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