FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002803923> ?p ?o ?g. }

• W2002803923 endingPage "570" @default.
• W2002803923 startingPage "555" @default.
• W2002803923 abstract "Ecdysteroids regulate many key developmental events in arthropods including molting and metamorphosis. Recently, members of the Drosophila Halloween group of genes, that are required for embryonic viability and cuticle deposition, have been shown to code for several cytochrome P450 enzymes that catalyze the terminal hydroxylation steps in the conversion of cholesterol to the molting hormone 20-hydroxyecdysone. These P450s are conserved in other insects and each is thought to function throughout development as the sole mediator of a particular biosynthetic step since, where analyzed, each is expressed at all stages of development and shows no closely related homolog in their respective genomes. In contrast, we show here that several dipteran genomes encode two novel, highly related, microsomal P450 enzymes, Cyp307A1 and Cyp307A2, that likely participate as stage-specific components of the ecdysone biosynthetic machinery. This hypothesis comes from the observation that Cyp307A1 is encoded by the Halloween gene spook (spo), but unlike other Halloween class genes, Dmspo is not expressed during the larval stages. In contrast, Cyp307a2, dubbed spookier (spok), is expressed primarily during larval stages within the prothoracic gland cells of the ring gland. RNAi mediated reduction in the expression of this heterochromatin localized gene leads to arrest at the first instar stage which can be rescued by feeding the larva 20E, E or ketodiol but not 7dC. In addition, spok expression is eliminated in larvae carrying mutations in molting defective (mld), a gene encoding a nuclear zinc finger protein that is required for production of ecdysone during Drosophila larval development. Intriguingly, mld is not present in the Bombyx mori genome, and we have identified only one spook homolog in both Bombyx and Manduca that is expressed in both embryos and larva. These studies suggest an evolutionary split between Diptera and Lepidoptera in how the ecdysone biosynthetic pathway is regulated during development." @default.
• W2002803923 created "2016-06-24" @default.
• W2002803923 creator A5020125684 @default.
• W2002803923 creator A5020126896 @default.
• W2002803923 creator A5021714553 @default.
• W2002803923 creator A5025345803 @default.
• W2002803923 creator A5041023442 @default.
• W2002803923 creator A5044937761 @default.
• W2002803923 creator A5049369167 @default.
• W2002803923 creator A5056336149 @default.
• W2002803923 creator A5057813286 @default.
• W2002803923 creator A5065780513 @default.
• W2002803923 creator A5079618494 @default.
• W2002803923 creator A5086070242 @default.
• W2002803923 date "2006-10-01" @default.
• W2002803923 modified "2023-10-18" @default.
• W2002803923 title "Spook and Spookier code for stage-specific components of the ecdysone biosynthetic pathway in Diptera" @default.
• W2002803923 cites W1682585074 @default.
• W2002803923 cites W1832760132 @default.
• W2002803923 cites W1971188096 @default.
• W2002803923 cites W1971528214 @default.
• W2002803923 cites W1973719695 @default.
• W2002803923 cites W1978383473 @default.
• W2002803923 cites W1984435541 @default.
• W2002803923 cites W1985074478 @default.
• W2002803923 cites W1993243680 @default.
• W2002803923 cites W1996985250 @default.
• W2002803923 cites W1997524493 @default.
• W2002803923 cites W1998119535 @default.
• W2002803923 cites W2000519009 @default.
• W2002803923 cites W2004145896 @default.
• W2002803923 cites W2006004899 @default.
• W2002803923 cites W2008548841 @default.
• W2002803923 cites W2017855403 @default.
• W2002803923 cites W2021554869 @default.
• W2002803923 cites W2032621098 @default.
• W2002803923 cites W2033048136 @default.
• W2002803923 cites W2036404561 @default.
• W2002803923 cites W2037206858 @default.
• W2002803923 cites W2039128629 @default.
• W2002803923 cites W2039174764 @default.
• W2002803923 cites W2046751665 @default.
• W2002803923 cites W2052828899 @default.
• W2002803923 cites W2057708838 @default.
• W2002803923 cites W2057904420 @default.
• W2002803923 cites W2058522782 @default.
• W2002803923 cites W2063689436 @default.
• W2002803923 cites W2075408686 @default.
• W2002803923 cites W2077271480 @default.
• W2002803923 cites W2079603189 @default.
• W2002803923 cites W2089312361 @default.
• W2002803923 cites W2096060868 @default.
• W2002803923 cites W2096960703 @default.
• W2002803923 cites W2109286448 @default.
• W2002803923 cites W2117622867 @default.
• W2002803923 cites W2125538185 @default.
• W2002803923 cites W2125971661 @default.
• W2002803923 cites W2139131906 @default.
• W2002803923 cites W2142160199 @default.
• W2002803923 cites W2144332892 @default.
• W2002803923 cites W2145201635 @default.
• W2002803923 cites W2149219387 @default.
• W2002803923 cites W2157228103 @default.
• W2002803923 cites W2157888086 @default.
• W2002803923 cites W2167730248 @default.
• W2002803923 cites W2169679662 @default.
• W2002803923 cites W2251431896 @default.
• W2002803923 cites W4250170407 @default.
• W2002803923 doi "https://doi.org/10.1016/j.ydbio.2006.07.023" @default.
• W2002803923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16949568" @default.
• W2002803923 hasPublicationYear "2006" @default.
• W2002803923 type Work @default.
• W2002803923 sameAs 2002803923 @default.
• W2002803923 citedByCount "276" @default.
• W2002803923 countsByYear W20028039232012 @default.
• W2002803923 countsByYear W20028039232013 @default.
• W2002803923 countsByYear W20028039232014 @default.
• W2002803923 countsByYear W20028039232015 @default.
• W2002803923 countsByYear W20028039232016 @default.
• W2002803923 countsByYear W20028039232017 @default.
• W2002803923 countsByYear W20028039232018 @default.
• W2002803923 countsByYear W20028039232019 @default.
• W2002803923 countsByYear W20028039232020 @default.
• W2002803923 countsByYear W20028039232021 @default.
• W2002803923 countsByYear W20028039232022 @default.
• W2002803923 countsByYear W20028039232023 @default.
• W2002803923 crossrefType "journal-article" @default.
• W2002803923 hasAuthorship W2002803923A5020125684 @default.
• W2002803923 hasAuthorship W2002803923A5020126896 @default.
• W2002803923 hasAuthorship W2002803923A5021714553 @default.
• W2002803923 hasAuthorship W2002803923A5025345803 @default.
• W2002803923 hasAuthorship W2002803923A5041023442 @default.
• W2002803923 hasAuthorship W2002803923A5044937761 @default.
• W2002803923 hasAuthorship W2002803923A5049369167 @default.
• W2002803923 hasAuthorship W2002803923A5056336149 @default.
• W2002803923 hasAuthorship W2002803923A5057813286 @default.
• W2002803923 hasAuthorship W2002803923A5065780513 @default.
• W2002803923 hasAuthorship W2002803923A5079618494 @default.

• next