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- W2002805952 endingPage "1448" @default.
- W2002805952 startingPage "1437" @default.
- W2002805952 abstract "Two principal pathways exist by which cells can undergo apoptotic death, known as the extrinsic and the intrinsic pathways. Binding of a ligand to a death receptor activates the extrinsic pathway. In the intrinsic pathway, an apoptotic stimulus, such as neurotrophin withdrawal or exposure to a toxin, causes a proapoptotic member of the Bcl-2 family of proteins, such as Bax, to permeabilize the outer mitochondrial membrane. This allows redistribution of cytochrome c from the mitochondrial intermembrane space into the cytoplasm, where it causes activation of caspase proteases and, subsequently, cell death. A dramatic increase occurs in mitochondria-derived reactive oxygen species (ROS) during the apoptotic death of sympathetic, cerebellar granule, and cortical neurons. These ROS lie downstream of Bax in each cell type. Here I review possible mechanisms by which Bax causes increased ROS during neuronal apoptosis. I also discuss evidence that these ROS are an important part of the apoptotic cascade in these cells. Finally, I discuss evidence that suggests that neurotrophins prevent release of cytochrome c in neurons through activation of an antioxidant pathway. Antioxid. Redox Signal. 14, 1437–1448." @default.
- W2002805952 created "2016-06-24" @default.
- W2002805952 creator A5086629164 @default.
- W2002805952 date "2011-04-15" @default.
- W2002805952 modified "2023-10-11" @default.
- W2002805952 title "Redox Regulation of the Intrinsic Pathway in Neuronal Apoptosis" @default.
- W2002805952 cites W1480948328 @default.
- W2002805952 cites W1507812324 @default.
- W2002805952 cites W1539880650 @default.
- W2002805952 cites W1540436551 @default.
- W2002805952 cites W1554372630 @default.
- W2002805952 cites W1566676785 @default.
- W2002805952 cites W1595656597 @default.
- W2002805952 cites W1607777232 @default.
- W2002805952 cites W1612119967 @default.
- W2002805952 cites W1612820086 @default.
- W2002805952 cites W1672183542 @default.
- W2002805952 cites W1824045762 @default.
- W2002805952 cites W1882516571 @default.
- W2002805952 cites W1940344336 @default.
- W2002805952 cites W1966176339 @default.
- W2002805952 cites W1966817531 @default.
- W2002805952 cites W1969331809 @default.
- W2002805952 cites W1970404834 @default.
- W2002805952 cites W1972317764 @default.
- W2002805952 cites W1972331889 @default.
- W2002805952 cites W1973760919 @default.
- W2002805952 cites W1980969730 @default.
- W2002805952 cites W1981106016 @default.
- W2002805952 cites W1981592463 @default.
- W2002805952 cites W1981684176 @default.
- W2002805952 cites W1982421412 @default.
- W2002805952 cites W1983678579 @default.
- W2002805952 cites W1985442766 @default.
- W2002805952 cites W1989224728 @default.
- W2002805952 cites W1990098732 @default.
- W2002805952 cites W1990458209 @default.
- W2002805952 cites W1992484817 @default.
- W2002805952 cites W1998961220 @default.
- W2002805952 cites W1999874768 @default.
- W2002805952 cites W2008597649 @default.
- W2002805952 cites W2009479459 @default.
- W2002805952 cites W2010083809 @default.
- W2002805952 cites W2010417870 @default.
- W2002805952 cites W2016293448 @default.
- W2002805952 cites W2020138346 @default.
- W2002805952 cites W2020600203 @default.
- W2002805952 cites W2025761257 @default.
- W2002805952 cites W2028914266 @default.
- W2002805952 cites W2029479814 @default.
- W2002805952 cites W2035127779 @default.
- W2002805952 cites W2036127346 @default.
- W2002805952 cites W2036411709 @default.
- W2002805952 cites W2039518578 @default.
- W2002805952 cites W2041289197 @default.
- W2002805952 cites W2042409437 @default.
- W2002805952 cites W2048750043 @default.
- W2002805952 cites W2052853635 @default.
- W2002805952 cites W2055615470 @default.
- W2002805952 cites W2060982272 @default.
- W2002805952 cites W2061114093 @default.
- W2002805952 cites W2063520227 @default.
- W2002805952 cites W2063960864 @default.
- W2002805952 cites W2064379451 @default.
- W2002805952 cites W2064470441 @default.
- W2002805952 cites W2069055691 @default.
- W2002805952 cites W2070764343 @default.
- W2002805952 cites W2070862399 @default.
- W2002805952 cites W2071179749 @default.
- W2002805952 cites W2073028327 @default.
- W2002805952 cites W2079705176 @default.
- W2002805952 cites W2083647969 @default.
- W2002805952 cites W2083854831 @default.
- W2002805952 cites W2085128107 @default.
- W2002805952 cites W2098227836 @default.
- W2002805952 cites W2101963635 @default.
- W2002805952 cites W2111757377 @default.
- W2002805952 cites W2117662018 @default.
- W2002805952 cites W2123113903 @default.
- W2002805952 cites W2123868590 @default.
- W2002805952 cites W2125779862 @default.
- W2002805952 cites W2134872883 @default.
- W2002805952 cites W2135874321 @default.
- W2002805952 cites W2144695914 @default.
- W2002805952 cites W2144701362 @default.
- W2002805952 cites W2148125367 @default.
- W2002805952 cites W2149065933 @default.
- W2002805952 cites W2151982496 @default.
- W2002805952 cites W2152165298 @default.
- W2002805952 cites W2153385508 @default.
- W2002805952 cites W2154745705 @default.
- W2002805952 cites W2158720649 @default.
- W2002805952 cites W2159650080 @default.
- W2002805952 cites W2161777274 @default.
- W2002805952 cites W2166451791 @default.
- W2002805952 cites W2166788705 @default.
- W2002805952 cites W2191713065 @default.
- W2002805952 cites W262542879 @default.