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- W2002807908 abstract "novel 21-AMINOSTEROID (U-74389G), a new potent antioxidant, was evaluated for its protective effect on ansient global cerebral ischemia. Ischemia was induced by 20 minutes of four-vessel occlusion in adult male Wistar ats. Injection of 21-aminosteroid (U-74389G, 5 mg/kg intraperitoneally injected) was repeated three times. The econd injection was performed 30 minutes after the first injection, and the third injection was performed 210 Rj linutes after that. Experimental animals were divided into five groups according to the time drug administration was litiated. Group I (n = 8) began vehicle administration 30 minutes before occlusion. Group II (n = 9) started 1-aminosteroid administration 30 minutes before occlusion. Drug administration in Group III (n = 9) began at the ime of reperfusion, in Group IV (n = 8), 30 minutes after reperfusion, and in Group V (n = 6), 60 minutes after t eperfusion. Animals in the control group (n = 5) underwent sham operations. One week after ischemia, the number j if viable pyramidal neurons was counted in the hippocampal CA1 subfield. The results were as follows: the number r if living neurons in Group I was 18.8 ± 8.7; in Group II, was 44.7 ± 9.5; in Group III, was 46.4 ± 9.4; in Group V, was 40.3 ± 6.6; in Group V, was 10.2 ± 2.5; and in the control group was 131 ± 3.3. Groups II, III, and IV lemonstrated significantly higher numbers of living neurons compared with Group I (P < 0.05). The present study evealed that U-74389G attenuated delayed neuronal death in global cerebral ischemia when it was administered lefore or soon after the ischemic episode." @default.
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- W2002807908 date "1996-03-01" @default.
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- W2002807908 title "Therapeutic Time Window for the 21-Aminosteroid, U-74389G, in Global Cerebral Ischemia" @default.
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- W2002807908 doi "https://doi.org/10.1097/00006123-199603000-00020" @default.
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