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- W2002809939 abstract "<i>Background:</i> Magnetic resonance imaging provides a noninvasive method to study the fate of transplanted cells in vivo. <i>Objective:</i> We studied the fate of embryonic and mesenchymal stem cells labeled with iron oxide nanoparticles (Endorem<sup>®</sup>) and human CD34+ cells labeled with magnetic MicroBeads (Miltenyi) in rats with a cortical or spinal cord lesion. <i>Methods:</i> Cells were grafted intracerebrally, contralaterally to a cortical photochemical lesion, or injected intravenously. <i>Results:</i> During the 1st week after transplantation, transplanted cells migrated to the lesion and were visible in the lesion on MR images as a hypointensive signal, persisting for more than 30 days. In rats with a balloon-induced spinal cord compression lesion, we observed an increase in functional recovery and hind limb sensitivity after implantation of Endorem-labeled mesenchymal stem cells or a freshly prepared mononuclear fraction of bone marrow cells or after injection of granulocyte colony-stimulating factor. Morphometric measurements in the center of the lesions showed an increase in white matter volume in cell-treated animals. Prussian blue staining confirmed a large number of Prussian blue-positive cells, and the lesions were considerably smaller than in control animals. <i>Conclusions:</i> These studies demonstrate that magnetic resonance imaging of grafted adult as well as embryonic stem cells labeled with iron oxide nanoparticles is a useful method for evaluating their migration and fate in CNS." @default.
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- W2002809939 date "2006-01-01" @default.
- W2002809939 modified "2023-10-02" @default.
- W2002809939 title "Magnetic Resonance Tracking of Transplanted Stem Cells in Rat Brain and Spinal Cord" @default.
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- W2002809939 doi "https://doi.org/10.1159/000092095" @default.
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