FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002818175> ?p ?o ?g. }

• W2002818175 endingPage "5390" @default.
• W2002818175 startingPage "5381" @default.
• W2002818175 abstract "ABSTRACT The recent outbreak of H7N9 influenza in China has resulted in many human cases with a high fatality rate. Poultry are the likely source of infection for humans on the basis of sequence analysis and virus isolations from live bird markets, but it is not clear which species of birds are most likely to be infected and shedding levels of virus sufficient to infect humans. Intranasal inoculation of chickens, Japanese quail, pigeons, Pekin ducks, Mallard ducks, Muscovy ducks, and Embden geese with 10 6 50% egg infective doses of the A/Anhui/1/2013 virus resulted in infection but no clinical disease signs. Virus shedding was much higher and prolonged in quail and chickens than in the other species. Quail effectively transmitted the virus to direct contacts, but pigeons and Pekin ducks did not. In all species, virus was detected at much higher titers from oropharyngeal swabs than cloacal swabs. The hemagglutinin gene from samples collected from selected experimentally infected birds was sequenced, and three amino acid differences were commonly observed when the sequence was compared to the sequence of A/Anhui/1/2013: N123D, N149D, and L217Q. Leucine at position 217 is highly conserved for human isolates and is associated with α2,6-sialic acid binding. Different amino acid combinations were observed, suggesting that the inoculum had viral subpopulations that were selected after passage in birds. These experimental studies corroborate the finding that certain poultry species are reservoirs of the H7N9 influenza virus and that the virus is highly tropic for the upper respiratory tract, so testing of bird species should preferentially be conducted with oropharyngeal swabs for the best sensitivity. IMPORTANCE The recent outbreak of H7N9 influenza in China has resulted in a number of human infections with a high case fatality rate. The source of the viral outbreak is suspected to be poultry, but definitive data on the source of the infection are not available. This study provides experimental data to show that quail and chickens are susceptible to infection, shed large amounts of virus, and are likely important in the spread of the virus to humans. Other poultry species can be infected and shed virus but are less likely to play a role of transmitting the virus to humans. Pigeons were previously suggested to be a possible source of the virus because of isolation of the virus from several pigeons in poultry markets in China, but experimental studies show that they are generally resistant to infection and are unlikely to play a role in the spread of the virus." @default.
• W2002818175 created "2016-06-24" @default.
• W2002818175 creator A5001722770 @default.
• W2002818175 creator A5045204229 @default.
• W2002818175 creator A5050674173 @default.
• W2002818175 creator A5054975268 @default.
• W2002818175 creator A5069055367 @default.
• W2002818175 creator A5084458656 @default.
• W2002818175 creator A5090505661 @default.
• W2002818175 date "2014-05-15" @default.
• W2002818175 modified "2023-10-11" @default.
• W2002818175 title "Role of Poultry in the Spread of Novel H7N9 Influenza Virus in China" @default.
• W2002818175 cites W139653013 @default.
• W2002818175 cites W1492839266 @default.
• W2002818175 cites W1523977236 @default.
• W2002818175 cites W1526257973 @default.
• W2002818175 cites W1944984183 @default.
• W2002818175 cites W1989481626 @default.
• W2002818175 cites W1991504928 @default.
• W2002818175 cites W1991607297 @default.
• W2002818175 cites W1999630079 @default.
• W2002818175 cites W2004396083 @default.
• W2002818175 cites W2012094117 @default.
• W2002818175 cites W2018150492 @default.
• W2002818175 cites W2023892549 @default.
• W2002818175 cites W2024811034 @default.
• W2002818175 cites W2027579505 @default.
• W2002818175 cites W2029890121 @default.
• W2002818175 cites W2032967479 @default.
• W2002818175 cites W2034970371 @default.
• W2002818175 cites W2035546162 @default.
• W2002818175 cites W2040707465 @default.
• W2002818175 cites W2050856597 @default.
• W2002818175 cites W2053172092 @default.
• W2002818175 cites W2054604776 @default.
• W2002818175 cites W2055995765 @default.
• W2002818175 cites W2066239994 @default.
• W2002818175 cites W2070331586 @default.
• W2002818175 cites W2077819494 @default.
• W2002818175 cites W2078437603 @default.
• W2002818175 cites W2081841371 @default.
• W2002818175 cites W2092097938 @default.
• W2002818175 cites W2096633302 @default.
• W2002818175 cites W2105226322 @default.
• W2002818175 cites W2106173155 @default.
• W2002818175 cites W2106919391 @default.
• W2002818175 cites W2113884542 @default.
• W2002818175 cites W2122256966 @default.
• W2002818175 cites W2125703277 @default.
• W2002818175 cites W2129146731 @default.
• W2002818175 cites W2130854633 @default.
• W2002818175 cites W2135745126 @default.
• W2002818175 cites W2136570341 @default.
• W2002818175 cites W2142827051 @default.
• W2002818175 cites W2143308104 @default.
• W2002818175 cites W2148734478 @default.
• W2002818175 cites W2150485802 @default.
• W2002818175 cites W2153782171 @default.
• W2002818175 cites W2154403354 @default.
• W2002818175 cites W2164121350 @default.
• W2002818175 cites W2164735009 @default.
• W2002818175 cites W2164906177 @default.
• W2002818175 cites W2167692034 @default.
• W2002818175 cites W2176066519 @default.
• W2002818175 cites W2178984576 @default.
• W2002818175 cites W2179163850 @default.
• W2002818175 cites W2275601789 @default.
• W2002818175 cites W2384357381 @default.
• W2002818175 cites W4236428829 @default.
• W2002818175 doi "https://doi.org/10.1128/jvi.03689-13" @default.
• W2002818175 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4019135" @default.
• W2002818175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24574407" @default.
• W2002818175 hasPublicationYear "2014" @default.
• W2002818175 type Work @default.
• W2002818175 sameAs 2002818175 @default.
• W2002818175 citedByCount "122" @default.
• W2002818175 countsByYear W20028181752014 @default.
• W2002818175 countsByYear W20028181752015 @default.
• W2002818175 countsByYear W20028181752016 @default.
• W2002818175 countsByYear W20028181752017 @default.
• W2002818175 countsByYear W20028181752018 @default.
• W2002818175 countsByYear W20028181752019 @default.
• W2002818175 countsByYear W20028181752020 @default.
• W2002818175 countsByYear W20028181752021 @default.
• W2002818175 countsByYear W20028181752022 @default.
• W2002818175 countsByYear W20028181752023 @default.
• W2002818175 crossrefType "journal-article" @default.
• W2002818175 hasAuthorship W2002818175A5001722770 @default.
• W2002818175 hasAuthorship W2002818175A5045204229 @default.
• W2002818175 hasAuthorship W2002818175A5050674173 @default.
• W2002818175 hasAuthorship W2002818175A5054975268 @default.
• W2002818175 hasAuthorship W2002818175A5069055367 @default.
• W2002818175 hasAuthorship W2002818175A5084458656 @default.
• W2002818175 hasAuthorship W2002818175A5090505661 @default.
• W2002818175 hasBestOaLocation W20028181751 @default.
• W2002818175 hasConcept C116675565 @default.
• W2002818175 hasConcept C12914427 @default.
• W2002818175 hasConcept C134215735 @default.

• next