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- W2002822014 abstract "Cellular oxidative stress promotes chemical reactions causing damage to DNA, proteins, and membranes. Here, we describe experiments indicating that reactive oxygen species, in addition to degrading polypeptides and polynucleotides through direct reactions, can also promote damaging biomolecular cross reactivity by converting protein residues into peroxides that cleave the DNA backbone. The studies reported show that a variety of residues induce strand scission upon oxidation, and hydrogen abstraction occurring at the DNA backbone is responsible for the damage. The observation of peptide-promoted DNA damage suggests that crossreactions within protein/DNA complexes should be considered as a significant cause of the toxicity of reactive oxygen species." @default.
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- W2002822014 date "2005-06-01" @default.
- W2002822014 modified "2023-10-01" @default.
- W2002822014 title "Oxidative DNA Strand Scission Induced by Peptides" @default.
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- W2002822014 doi "https://doi.org/10.1016/j.chembiol.2005.04.015" @default.
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