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• W2002830539 abstract "Abstract Background: Activation products from neutrophils and the complement system might cause endothelial dysfunction, which is central to the aetiology of pre‐eclampsia. This study aimed to investigate the activity of myeloperoxidase (MPO), and its association with advanced oxidation protein products (AOPP), in women with pre‐eclampsia and eclampsia. Materials and method: Twenty‐one pregnant women with pre‐eclampsia, 11 pregnant women with eclampsia and 19 healthy pregnant women were studied. Serum levels of malondialdehyde (MDA), AOPP, ascorbic acid (AA) and activities of MPO and catalase (CAT) were measured using a colorimetric method. Results: The MDA level was significantly higher in the pre‐eclampsia (3.15 ± 0.28 nmol/mL) and eclampsia (4.01 ± 0.66 nmol/mL) groups than in controls (1.85 ± 0.18 nmol/mL); the difference between MDA levels in the pre‐eclampsia and eclampsia groups was not statistically significant. MPO activity was significantly higher in the eclampsia (347.59 ± 88.06 U/L) group than in the pre‐eclampsia (196.17 ± 30.8) and control (93.22 ± 9.52) groups, and there was also no significant difference in these levels between the pre‐eclampsia and control groups. CAT activity was significantly higher in the pre‐eclampsia (166.35 ± 31.75 U/L) and eclampsia (166.98 ± 40.31 U/L) groups than in controls (81.28 ± 7.41 U/L), and AA level was significantly higher in the pre‐eclampsia (0.54 ± 0.15 mg/dL) group than in controls (0.18 ± 0.01 mg/dL); the differences in AA and CAT activity between the pre‐eclampsia and eclampsia groups were not statistically significant. AOPP levels did not change significantly among the control, pre‐eclampsia and eclampsia groups (106.88 ± 5.62, 98.89 ± 6.47, 111.89 ± 6.8 µmol/L, respectively). Conclusions: We suggest that increased oxidative stress might contribute to the pathophysiological mechanisms of pre‐eclampsia and eclampsia, and that AA and CAT might have a protective role via free radical‐scavenging properties. However, further study is needed." @default.
• W2002830539 created "2016-06-24" @default.
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• W2002830539 date "2006-11-14" @default.
• W2002830539 modified "2023-10-17" @default.
• W2002830539 title "Serum advanced oxidation protein products, myeloperoxidase and ascorbic acid in pre-eclampsia and eclampsia" @default.
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• W2002830539 doi "https://doi.org/10.1111/j.1479-828x.2006.00647.x" @default.
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