FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002862118> ?p ?o ?g. }

• W2002862118 endingPage "467" @default.
• W2002862118 startingPage "458" @default.
• W2002862118 abstract "Abstract Considerable evidence indicates that the amyloid‐β (Aβ) peptide, a proteolytic fragment of the amyloid precursor protein, is the pathogenic agent in Alzheimer's disease (AD). A number of proteases have been reported as capable of degrading Aβ, among them: neprilysin, insulin‐degrading enzyme, endothelin‐converting enzyme‐1 and ‐2, angiotensin‐converting enzyme and plasmin. These proteases, originating from a variety of cell types, degrade Aβ of various conformational states and in different cellular locations. We report here the isolation of a serine protease from serum‐free conditioned medium of human neuroblastoma cells. Tandem mass spectrometry (MS/MS)‐based sequencing of the isolated protein identified acyl peptide hydrolase (APH; EC3.4.19.1) as the active peptidase. APH is one of four members of the prolyl oligopeptidase family of serine proteases expressed in a variety of cells and tissues, including erythrocytes, liver and brain, but its precise biological activity is unknown. Here, we describe the identification of APH as an Aβ‐degrading enzyme, and we show that the degradation of Aβ by APH isolated from transfected cells is inhibited by APH‐specific inhibitors, as well as by synthetic Aβ peptide. In addition, we cloned APH from human brain and from neuroblastoma cells. Most importantly, our results indicate that APH expression in AD brain is lower than in age‐matched controls." @default.
• W2002862118 created "2016-06-24" @default.
• W2002862118 creator A5005401916 @default.
• W2002862118 creator A5020843101 @default.
• W2002862118 creator A5052419811 @default.
• W2002862118 creator A5067452925 @default.
• W2002862118 creator A5078680549 @default.
• W2002862118 creator A5078699806 @default.
• W2002862118 date "2006-10-02" @default.
• W2002862118 modified "2023-10-16" @default.
• W2002862118 title "Acyl peptide hydrolase, a serine proteinase isolated from conditioned medium of neuroblastoma cells, degrades the amyloid-? peptide" @default.
• W2002862118 cites W1565361955 @default.
• W2002862118 cites W1569630040 @default.
• W2002862118 cites W1575225446 @default.
• W2002862118 cites W1592218319 @default.
• W2002862118 cites W1971058118 @default.
• W2002862118 cites W1971617039 @default.
• W2002862118 cites W1973247083 @default.
• W2002862118 cites W1980477960 @default.
• W2002862118 cites W1984243890 @default.
• W2002862118 cites W1994580857 @default.
• W2002862118 cites W1998208719 @default.
• W2002862118 cites W2008613466 @default.
• W2002862118 cites W2011865071 @default.
• W2002862118 cites W2019042091 @default.
• W2002862118 cites W2032477994 @default.
• W2002862118 cites W2032920422 @default.
• W2002862118 cites W2033825402 @default.
• W2002862118 cites W2035316083 @default.
• W2002862118 cites W2036934557 @default.
• W2002862118 cites W2046847750 @default.
• W2002862118 cites W2049711833 @default.
• W2002862118 cites W2051406514 @default.
• W2002862118 cites W2054753720 @default.
• W2002862118 cites W2057245657 @default.
• W2002862118 cites W2059214757 @default.
• W2002862118 cites W2076016822 @default.
• W2002862118 cites W2084917929 @default.
• W2002862118 cites W2108328125 @default.
• W2002862118 cites W2117983251 @default.
• W2002862118 cites W2125516765 @default.
• W2002862118 cites W2138369511 @default.
• W2002862118 cites W2140260680 @default.
• W2002862118 cites W2148516306 @default.
• W2002862118 cites W2164672119 @default.
• W2002862118 cites W2170262566 @default.
• W2002862118 cites W2184058391 @default.
• W2002862118 cites W2249486297 @default.
• W2002862118 doi "https://doi.org/10.1111/j.1471-4159.2006.04251.x" @default.
• W2002862118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17241160" @default.
• W2002862118 hasPublicationYear "2006" @default.
• W2002862118 type Work @default.
• W2002862118 sameAs 2002862118 @default.
• W2002862118 citedByCount "36" @default.
• W2002862118 countsByYear W20028621182012 @default.
• W2002862118 countsByYear W20028621182013 @default.
• W2002862118 countsByYear W20028621182014 @default.
• W2002862118 countsByYear W20028621182015 @default.
• W2002862118 countsByYear W20028621182016 @default.
• W2002862118 countsByYear W20028621182017 @default.
• W2002862118 countsByYear W20028621182018 @default.
• W2002862118 countsByYear W20028621182019 @default.
• W2002862118 countsByYear W20028621182021 @default.
• W2002862118 countsByYear W20028621182023 @default.
• W2002862118 crossrefType "journal-article" @default.
• W2002862118 hasAuthorship W2002862118A5005401916 @default.
• W2002862118 hasAuthorship W2002862118A5020843101 @default.
• W2002862118 hasAuthorship W2002862118A5052419811 @default.
• W2002862118 hasAuthorship W2002862118A5067452925 @default.
• W2002862118 hasAuthorship W2002862118A5078680549 @default.
• W2002862118 hasAuthorship W2002862118A5078699806 @default.
• W2002862118 hasConcept C104826730 @default.
• W2002862118 hasConcept C142724271 @default.
• W2002862118 hasConcept C153911025 @default.
• W2002862118 hasConcept C181199279 @default.
• W2002862118 hasConcept C182220744 @default.
• W2002862118 hasConcept C185592680 @default.
• W2002862118 hasConcept C2776414213 @default.
• W2002862118 hasConcept C2776714187 @default.
• W2002862118 hasConcept C2777807008 @default.
• W2002862118 hasConcept C2779134260 @default.
• W2002862118 hasConcept C2779281246 @default.
• W2002862118 hasConcept C2780043585 @default.
• W2002862118 hasConcept C2909000736 @default.
• W2002862118 hasConcept C31705614 @default.
• W2002862118 hasConcept C502032728 @default.
• W2002862118 hasConcept C55493867 @default.
• W2002862118 hasConcept C71924100 @default.
• W2002862118 hasConcept C86803240 @default.
• W2002862118 hasConceptScore W2002862118C104826730 @default.
• W2002862118 hasConceptScore W2002862118C142724271 @default.
• W2002862118 hasConceptScore W2002862118C153911025 @default.
• W2002862118 hasConceptScore W2002862118C181199279 @default.
• W2002862118 hasConceptScore W2002862118C182220744 @default.
• W2002862118 hasConceptScore W2002862118C185592680 @default.
• W2002862118 hasConceptScore W2002862118C2776414213 @default.
• W2002862118 hasConceptScore W2002862118C2776714187 @default.
• W2002862118 hasConceptScore W2002862118C2777807008 @default.

• next