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• W2002869490 abstract "Abstract Susceptibility to neuroinflammatory disease is influenced in part by genetics. Recent data indicate that survival of traumatized neurons is strain dependent and influenced by polygenic loci that control resistance/susceptibility to experimental autoimmune encephalomyelitis (EAE), a model of CNS autoimmune disease. Here, we describe patterns of neurodegeneration and intraparenchymal inflammation after traumatic spinal cord injury (SCI) in mice known to exhibit varying degrees of EAE susceptibility [EAE‐resistant (r) or EAE‐susceptible (s) mice]. Spinal cords from C57BL/6 (EAE‐s), C57BL/10 (EAE‐r), BALB/c (EAE‐r), and B10.PL (EAE‐s) mice were prepared for stereological and immunohistochemical analysis at 6 hours or 3, 7, 14, 28, or 42 days following midthoracic (T9) spinal contusion injury. In general, genetic predisposition to EAE predicted the magnitude of intraparenchymal inflammation but not lesion size/length or locomotor recovery. Specifically, microglia/macrophage activation, recruitment of neutrophils and lymphocytes, and de novo synthesis of MHC class II were greatest in C57BL/6 mice and least in BALB/c mice at all times examined. However, lesion volume and axial spread of neurodegeneration were similar in C57BL/6 and BALB/c mice and were significantly greater than in C57BL/10 or B10.PL mice. Strains with marked intraspinal inflammation also developed the most intense lesion fibrosis. Thus, strain‐dependent neuroinflammation was observed after SCI, but without a consistent relationship to EAE susceptibility or lesion progression. Only in C57BL/6 mice was the magnitude of intraspinal inflammation predictive of secondary neurodegeneration, functional recovery, or fibrosis. J. Comp. Neurol. 494:578–594, 2006. © 2005 Wiley‐Liss, Inc." @default.
• W2002869490 created "2016-06-24" @default.
• W2002869490 creator A5005712332 @default.
• W2002869490 creator A5012696999 @default.
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• W2002869490 date "2005-12-22" @default.
• W2002869490 modified "2023-10-12" @default.
• W2002869490 title "Comparative analysis of lesion development and intraspinal inflammation in four strains of mice following spinal contusion injury" @default.
• W2002869490 cites W1487373628 @default.
• W2002869490 cites W1490103513 @default.
• W2002869490 cites W1533530009 @default.
• W2002869490 cites W1542844386 @default.
• W2002869490 cites W1590710381 @default.
• W2002869490 cites W1622739787 @default.
• W2002869490 cites W1632883247 @default.
• W2002869490 cites W1668344921 @default.
• W2002869490 cites W1677534473 @default.
• W2002869490 cites W1719351096 @default.
• W2002869490 cites W1753183749 @default.
• W2002869490 cites W1769737355 @default.
• W2002869490 cites W1789825727 @default.
• W2002869490 cites W1875254393 @default.
• W2002869490 cites W1908112684 @default.
• W2002869490 cites W1977841940 @default.
• W2002869490 cites W1977917555 @default.
• W2002869490 cites W1979209500 @default.
• W2002869490 cites W1979463760 @default.
• W2002869490 cites W1979541355 @default.
• W2002869490 cites W1983273975 @default.
• W2002869490 cites W1985263564 @default.
• W2002869490 cites W1988042413 @default.
• W2002869490 cites W1988726352 @default.
• W2002869490 cites W1988976635 @default.
• W2002869490 cites W1994416240 @default.
• W2002869490 cites W2001748009 @default.
• W2002869490 cites W2001758550 @default.
• W2002869490 cites W2003675005 @default.
• W2002869490 cites W2006196877 @default.
• W2002869490 cites W2011411078 @default.
• W2002869490 cites W2012299945 @default.
• W2002869490 cites W2013683961 @default.
• W2002869490 cites W2016746441 @default.
• W2002869490 cites W2023318533 @default.
• W2002869490 cites W2024535835 @default.
• W2002869490 cites W2024953914 @default.
• W2002869490 cites W2029593537 @default.
• W2002869490 cites W2033068332 @default.
• W2002869490 cites W2033605190 @default.
• W2002869490 cites W2035274471 @default.
• W2002869490 cites W2038293269 @default.
• W2002869490 cites W2039420382 @default.
• W2002869490 cites W2041800999 @default.
• W2002869490 cites W2049122724 @default.
• W2002869490 cites W2049521887 @default.
• W2002869490 cites W2053084751 @default.
• W2002869490 cites W2056610728 @default.
• W2002869490 cites W2059028717 @default.
• W2002869490 cites W2062937749 @default.
• W2002869490 cites W2064937772 @default.
• W2002869490 cites W2066991415 @default.
• W2002869490 cites W2068360183 @default.
• W2002869490 cites W2080274411 @default.
• W2002869490 cites W2085716611 @default.
• W2002869490 cites W2089757433 @default.
• W2002869490 cites W2091946061 @default.
• W2002869490 cites W2093738970 @default.
• W2002869490 cites W2098734841 @default.
• W2002869490 cites W2099579812 @default.
• W2002869490 cites W2104660263 @default.
• W2002869490 cites W2107826905 @default.
• W2002869490 cites W2109272101 @default.
• W2002869490 cites W2122662265 @default.
• W2002869490 cites W2133621763 @default.
• W2002869490 cites W2142847927 @default.
• W2002869490 cites W2145489141 @default.
• W2002869490 cites W2148772680 @default.
• W2002869490 cites W2152734743 @default.
• W2002869490 cites W2153404483 @default.
• W2002869490 cites W2155516436 @default.
• W2002869490 cites W2159006701 @default.
• W2002869490 cites W2159775713 @default.
• W2002869490 cites W2168424667 @default.
• W2002869490 cites W2168655254 @default.
• W2002869490 cites W2332123736 @default.
• W2002869490 cites W2346410706 @default.
• W2002869490 cites W2399788710 @default.
• W2002869490 cites W2410982626 @default.
• W2002869490 cites W246030600 @default.
• W2002869490 cites W3355293 @default.
• W2002869490 cites W4248565951 @default.
• W2002869490 cites W4322377755 @default.
• W2002869490 cites W52558577 @default.
• W2002869490 doi "https://doi.org/10.1002/cne.20827" @default.
• W2002869490 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2655318" @default.
• W2002869490 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16374800" @default.
• W2002869490 hasPublicationYear "2005" @default.
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