FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002876998> ?p ?o ?g. }

• W2002876998 endingPage "64" @default.
• W2002876998 startingPage "57" @default.
• W2002876998 abstract "The effect of mild acute tubular injury on the progression of tubulointerstitial fibrosis was studied in pair‐fed uninephrectomized male Wistar rats with established adriamycin nephrosis ( n =34). Rats were stratified into three groups according to endogenous creatinine clearance (CrCl), proteinuria (Upr) and body weight (BW): (i) group 1 (Fe, n =12) received a single intraperitoneal injection of ferric nitrilotriacetate (5 mg Fe/kg BW); (ii) group 2 (G, n =10) three daily subcutaneous injections of gentamicin (60 mg/kg BW) and; (iii) group 3 (C, n =12) saline injections. Serial CrCl (day 2, day 5, weeks 2, 4, 6 and 8) and renal histology (week 8) were examined following administration of nephrotoxin. CrCl was reduced on d2 (Fe: 0.78±0.23 mL/min; mean±SD) and day 5 (G: 0.91±0.36 mL/min) as compared with C (1.22±0.12 mL/min; P <0.05). There was no change in the serum creatinine and functional recovery occurred by d5 (Fe) and week 2 (G). Upr decreased transiently in G at week 2 (G: 482±208 mg/day vs C: 716±233; P =0.05) despite similar food intake, baseline Upr and CrCl. At week 8, CrCl in Fe (0.84±0.40 mL/min) was similar to C (0.84±0.58 mL/min), whereas in G it remained stable (1.27±0.39 mL/min; P <0.05). By morphometric analysis, mean relative interstitial volume (RIV) and glomerulosclerosis (GS) in Fe (RIV: 28.5±13.4%; GS: 10.3±12.3%) was no different to C (RIV: 24.5±12.5%; GS: 20.9±20.0%), whereas both parameters were reduced in G (RIV: 14.1±8.1%; GS: 4.0±4.8%; P <0.05). Mild gentamicin nephrotoxicity therefore reduced the progression of adriamycin nephrosis. The mechanism of this finding is unclear, but it may relate to altered glomerular and tubular cell handling of protein." @default.
• W2002876998 created "2016-06-24" @default.
• W2002876998 creator A5000245536 @default.
• W2002876998 creator A5013255054 @default.
• W2002876998 creator A5036294739 @default.
• W2002876998 creator A5040533032 @default.
• W2002876998 creator A5074760833 @default.
• W2002876998 date "1998-02-01" @default.
• W2002876998 modified "2023-10-16" @default.
• W2002876998 title "Mild gentamicin nephrotoxicity reduces the progression of chronic adriamycin nephrosis" @default.
• W2002876998 cites W101008474 @default.
• W2002876998 cites W103037428 @default.
• W2002876998 cites W106016309 @default.
• W2002876998 cites W1962102489 @default.
• W2002876998 cites W1964920299 @default.
• W2002876998 cites W1976367987 @default.
• W2002876998 cites W1976878327 @default.
• W2002876998 cites W1980102164 @default.
• W2002876998 cites W1984229760 @default.
• W2002876998 cites W1986459335 @default.
• W2002876998 cites W1986553082 @default.
• W2002876998 cites W1989824948 @default.
• W2002876998 cites W2002384775 @default.
• W2002876998 cites W2009298951 @default.
• W2002876998 cites W2009326258 @default.
• W2002876998 cites W2012578278 @default.
• W2002876998 cites W2017415809 @default.
• W2002876998 cites W2026315611 @default.
• W2002876998 cites W2026989260 @default.
• W2002876998 cites W2031943611 @default.
• W2002876998 cites W2033102850 @default.
• W2002876998 cites W2040592282 @default.
• W2002876998 cites W2064187936 @default.
• W2002876998 cites W2069018126 @default.
• W2002876998 cites W2072755542 @default.
• W2002876998 cites W2073017037 @default.
• W2002876998 cites W2074563683 @default.
• W2002876998 cites W2094116526 @default.
• W2002876998 cites W2102221011 @default.
• W2002876998 cites W2145902340 @default.
• W2002876998 cites W2147348512 @default.
• W2002876998 cites W2278106111 @default.
• W2002876998 cites W2286727159 @default.
• W2002876998 cites W2406192603 @default.
• W2002876998 cites W2409390336 @default.
• W2002876998 cites W2410789192 @default.
• W2002876998 cites W2412137928 @default.
• W2002876998 cites W2412240304 @default.
• W2002876998 cites W2465528514 @default.
• W2002876998 cites W2791764865 @default.
• W2002876998 cites W32071582 @default.
• W2002876998 cites W78647631 @default.
• W2002876998 doi "https://doi.org/10.1046/j.1440-1797.1998.d01-11.x" @default.
• W2002876998 hasPublicationYear "1998" @default.
• W2002876998 type Work @default.
• W2002876998 sameAs 2002876998 @default.
• W2002876998 citedByCount "4" @default.
• W2002876998 countsByYear W20028769982015 @default.
• W2002876998 countsByYear W20028769982019 @default.
• W2002876998 crossrefType "journal-article" @default.
• W2002876998 hasAuthorship W2002876998A5000245536 @default.
• W2002876998 hasAuthorship W2002876998A5013255054 @default.
• W2002876998 hasAuthorship W2002876998A5036294739 @default.
• W2002876998 hasAuthorship W2002876998A5040533032 @default.
• W2002876998 hasAuthorship W2002876998A5074760833 @default.
• W2002876998 hasConcept C126189478 @default.
• W2002876998 hasConcept C126322002 @default.
• W2002876998 hasConcept C126894567 @default.
• W2002876998 hasConcept C134018914 @default.
• W2002876998 hasConcept C159641895 @default.
• W2002876998 hasConcept C185592680 @default.
• W2002876998 hasConcept C2775832221 @default.
• W2002876998 hasConcept C2777397205 @default.
• W2002876998 hasConcept C2779561371 @default.
• W2002876998 hasConcept C2780091579 @default.
• W2002876998 hasConcept C2780306776 @default.
• W2002876998 hasConcept C2781175652 @default.
• W2002876998 hasConcept C501593827 @default.
• W2002876998 hasConcept C55493867 @default.
• W2002876998 hasConcept C71924100 @default.
• W2002876998 hasConceptScore W2002876998C126189478 @default.
• W2002876998 hasConceptScore W2002876998C126322002 @default.
• W2002876998 hasConceptScore W2002876998C126894567 @default.
• W2002876998 hasConceptScore W2002876998C134018914 @default.
• W2002876998 hasConceptScore W2002876998C159641895 @default.
• W2002876998 hasConceptScore W2002876998C185592680 @default.
• W2002876998 hasConceptScore W2002876998C2775832221 @default.
• W2002876998 hasConceptScore W2002876998C2777397205 @default.
• W2002876998 hasConceptScore W2002876998C2779561371 @default.
• W2002876998 hasConceptScore W2002876998C2780091579 @default.
• W2002876998 hasConceptScore W2002876998C2780306776 @default.
• W2002876998 hasConceptScore W2002876998C2781175652 @default.
• W2002876998 hasConceptScore W2002876998C501593827 @default.
• W2002876998 hasConceptScore W2002876998C55493867 @default.
• W2002876998 hasConceptScore W2002876998C71924100 @default.
• W2002876998 hasIssue "1" @default.
• W2002876998 hasLocation W20028769981 @default.
• W2002876998 hasOpenAccess W2002876998 @default.

• next