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- W2002879831 endingPage "77" @default.
- W2002879831 startingPage "69" @default.
- W2002879831 abstract "The microenvironment of established tumours is often immunosuppressed, and this allows tumours to grow and disseminate without being eliminated by the patient's immune system. The recent FDA approval of immunotherapies such as ipilimumab and sipuleucel-T that directly activate the adaptive and innate immune responses has triggered interest in developing other novel anti-cancer approaches that modulate the immune system. Understanding how the different constituents of the tumour microenvironment influence the immune system is thus crucial and is expected to generate a plethora of factors that can be targeted to boost immunity and trigger long lasting anti-tumour efficacy. Cancer associated fibroblasts (CAFs) are a crucial component of the tumour microenvironment. Through secretion of multiple growth factors, cytokines and proteases, CAFs are known to be key effectors for tumour progression and can promote cancer cell growth, invasiveness and angiogenesis. However, recent publications have also linked CAF biology to innate and adaptive immune cell recruitment and regulation. Here, we review recent findings on how CAFs can influence the immune status of tumours through direct and indirect interaction with immune cells and other key components of the tumour microenvironment." @default.
- W2002879831 created "2016-06-24" @default.
- W2002879831 creator A5076265076 @default.
- W2002879831 creator A5086626034 @default.
- W2002879831 date "2014-04-01" @default.
- W2002879831 modified "2023-09-30" @default.
- W2002879831 title "Regulation of the anti-tumour immune response by cancer-associated fibroblasts" @default.
- W2002879831 cites W1571628027 @default.
- W2002879831 cites W1619959770 @default.
- W2002879831 cites W1640854798 @default.
- W2002879831 cites W1790309941 @default.
- W2002879831 cites W1912639232 @default.
- W2002879831 cites W1931315964 @default.
- W2002879831 cites W1939910265 @default.
- W2002879831 cites W1957390836 @default.
- W2002879831 cites W1965691956 @default.
- W2002879831 cites W1972196680 @default.
- W2002879831 cites W1977381126 @default.
- W2002879831 cites W1977524356 @default.
- W2002879831 cites W1979990833 @default.
- W2002879831 cites W1982226677 @default.
- W2002879831 cites W1983575915 @default.
- W2002879831 cites W1983874247 @default.
- W2002879831 cites W1985157285 @default.
- W2002879831 cites W1988839887 @default.
- W2002879831 cites W1989434167 @default.
- W2002879831 cites W1990214118 @default.
- W2002879831 cites W1991370238 @default.
- W2002879831 cites W1993965822 @default.
- W2002879831 cites W1995481385 @default.
- W2002879831 cites W2002689409 @default.
- W2002879831 cites W2005203470 @default.
- W2002879831 cites W2006982681 @default.
- W2002879831 cites W2008104067 @default.
- W2002879831 cites W2009729813 @default.
- W2002879831 cites W2015028428 @default.
- W2002879831 cites W2015616022 @default.
- W2002879831 cites W2016008825 @default.
- W2002879831 cites W2019609336 @default.
- W2002879831 cites W2021826830 @default.
- W2002879831 cites W2026067651 @default.
- W2002879831 cites W2026302623 @default.
- W2002879831 cites W2026813843 @default.
- W2002879831 cites W2029650614 @default.
- W2002879831 cites W2030739171 @default.
- W2002879831 cites W2034269086 @default.
- W2002879831 cites W2041433337 @default.
- W2002879831 cites W2043503111 @default.
- W2002879831 cites W2048253455 @default.
- W2002879831 cites W2056574134 @default.
- W2002879831 cites W2056738135 @default.
- W2002879831 cites W2059471078 @default.
- W2002879831 cites W2061581062 @default.
- W2002879831 cites W2062809449 @default.
- W2002879831 cites W2067212128 @default.
- W2002879831 cites W2070636596 @default.
- W2002879831 cites W2072483737 @default.
- W2002879831 cites W2074604431 @default.
- W2002879831 cites W2075465677 @default.
- W2002879831 cites W2079501827 @default.
- W2002879831 cites W2086834665 @default.
- W2002879831 cites W2089251684 @default.
- W2002879831 cites W2089723196 @default.
- W2002879831 cites W2100303404 @default.
- W2002879831 cites W2101037339 @default.
- W2002879831 cites W2102031533 @default.
- W2002879831 cites W2103883318 @default.
- W2002879831 cites W2105055793 @default.
- W2002879831 cites W2105241495 @default.
- W2002879831 cites W2107441200 @default.
- W2002879831 cites W2107498524 @default.
- W2002879831 cites W2108984461 @default.
- W2002879831 cites W2111290954 @default.
- W2002879831 cites W2111547416 @default.
- W2002879831 cites W2111895881 @default.
- W2002879831 cites W2114050989 @default.
- W2002879831 cites W2115843698 @default.
- W2002879831 cites W2116813877 @default.
- W2002879831 cites W2117073896 @default.
- W2002879831 cites W2117692326 @default.
- W2002879831 cites W2118278569 @default.
- W2002879831 cites W2118323175 @default.
- W2002879831 cites W2118982164 @default.
- W2002879831 cites W2124846832 @default.
- W2002879831 cites W2125156205 @default.
- W2002879831 cites W2126868151 @default.
- W2002879831 cites W2132566055 @default.
- W2002879831 cites W2135907850 @default.
- W2002879831 cites W2143163879 @default.
- W2002879831 cites W2149336558 @default.
- W2002879831 cites W2150393634 @default.
- W2002879831 cites W2151832198 @default.
- W2002879831 cites W2154061152 @default.
- W2002879831 cites W2154670252 @default.
- W2002879831 cites W2155662291 @default.
- W2002879831 cites W2158642531 @default.
- W2002879831 cites W2159087758 @default.
- W2002879831 cites W2160909976 @default.