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• W2002912229 abstract "High specific radioactivity is preferable in the measurement of neuroreceptor bindings with positron emission tomography (PET) because receptor occupancy by mixed cold ligand hampers the accurate estimation of receptor binding. Recently, we succeeded in synthesizing [(11)C]raclopride, a dopamine D(2) receptor ligand, with ultra-high specific radioactivity, i.e., several thousand GBq/μmol. In the present study, we compared the [(11)C]raclopride bindings to dopamine D(2) receptors between radioligands with ultra-high specific radioactivity and ordinary high specific radioactivity in healthy human subjects.Two PET studies using [(11)C]raclopride with ultra-high specific radioactivity (4302-7222 GBq/μmol) or ordinary high specific radioactivity (133-280 GBq/μmol) were performed on different days in 14 healthy men. Binding potential (BP) was calculated by the simplified reference tissue method, peak equilibrium method, and area-under-the-curve method for each region-of-interest using time-activity data in the cerebellum as a reference brain region.BP values for radioligands with ultra-high specific radioactivity and ordinary high specific radioactivity calculated by the simplified reference tissue method were 4.06 ± 0.29 and 4.10 ± 0.25 in the putamen, 0.44 ± 0.07 and 0.47 ± 0.07 in the thalamus and 0.37 ± 0.06 and 0.38 ± 0.06 in the temporal cortex, respectively (mean ± S.D.). No significant difference in BP was observed between ultra-high specific radioactivity and ordinary high specific radioactivity in any of the brain regions.BP values of [(11)C]raclopride with ultra-high specific radioactivity did not differ from those with ordinary high specific radioactivity in the measured brain regions, including striatal and extrastriatal regions." @default.
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• W2002912229 date "2010-10-01" @default.
• W2002912229 modified "2023-10-14" @default.
• W2002912229 title "Measurement of dopamine D2 receptors in living human brain using [11C]raclopride with ultra-high specific radioactivity" @default.
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• W2002912229 doi "https://doi.org/10.1016/j.nucmedbio.2010.04.138" @default.
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